Health-Related Quality of Life Subdomains in Patients with Parkinson's Disease: The Role of Gender

Parkinson's Disease
Anja OpheyElke Kalbe

Abstract

The most frequently used instrument to assess health-related quality of life (HrQoL) in Parkinson's disease (PD) is the Parkinson's Disease Questionnaire 39 (PDQ-39). However, both the dimensionality of the eight PDQ-39 subscales and their summary score recently faced criticism. Furthermore, data on disease-related and neuropsychological determinants and the role of gender on HrQoL in PD are inconclusive yet. Therefore, our aim was to reevaluate the PDQ-39 structure and to further explore determinants of HrQoL in PD. 245 PD patients (age: M = 69.64, SD = 8.43; 62.9% male; H&Y: Md = 3.00; cognitive assessment with PANDA: M = 24.82, SD = 3.57) from the baseline database of the Cologne Parkinson Network were used to reevaluate the dimensionality of the PDQ-39 with a principal component analysis (PCA). Multiple regression analyses were conducted to clarify general and domain-specific relationships between clinical, (neuro)psychological, and sociodemographic variables, gender in particular, and HrQoL. The PCA identified three HrQoL domains: physical-functioning, cognition, and socioemotional HrQoL. Depressive symptoms were identified as the most important determinant of HrQoL across all models. Disease-related HrQoL determinants (UP...Continue Reading

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Citations

Aug 21, 2019·Frontiers in Neurology·Mariano SerraoFrancesco Pierelli
Sep 26, 2020·Frontiers in Aging Neuroscience·Yun FanYilin Tang
Jan 2, 2021·International Journal of Environmental Research and Public Health·Pietro CrispinoMarco Vacante
Sep 16, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Alicia Gonzalez-MartinezMaría De Toledo-Heras

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