Health-related quality of life up to six years after (125)I brachytherapy for early-stage prostate cancer

International Journal of Radiation Oncology, Biology, Physics
Ellen M A RoeloffzenMarco van Vulpen

Abstract

Health-related quality of life (HRQOL) after prostate brachytherapy has been extensively described in published reports but hardly any long-term data are available. The aim of the present study was to prospectively assess long-term HRQOL 6 years after (125)I prostate brachytherapy. A total of 127 patients treated with (125)I brachytherapy for early-stage prostate cancer between December 2000 and June 2003 completed a HRQOL questionnaire at five time-points: before treatment and 1 month, 6 months, 1 year, and 6 years after treatment. The questionnaire included the RAND-36 generic health survey, the cancer-specific European Organization for Research and Treatment of Cancer core questionnaire (EORTCQLQ-C30), and the tumor-specific EORTC prostate cancer module (EORTC-PR25). A change in a score of >/=10 points was considered clinically relevant. Overall, the HRQOL at 6 years after (125)I prostate brachytherapy did not significantly differ from baseline. Although a statistically significant deterioration in HRQOL at 6 years was seen for urinary symptoms, bowel symptoms, pain, physical functioning, and sexual activity (p <.01), most changes were not clinically relevant. A statistically significant improvement at 6 years was seen for m...Continue Reading

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Citations

Nov 27, 2009·International Journal of Radiation Oncology, Biology, Physics·Ellen M A RoeloffzenMarco van Vulpen
Sep 28, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Shafak AluwiniInger-Karine K Kolkman-Deurloo
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Mar 31, 2012·Brachytherapy·Victoria G JongkampMarco van Vulpen
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Aug 12, 2015·BJU International·Michael Wt ChaoNathan Lawrentschuk
Mar 23, 2021·Brachytherapy·Elizabeth Thompson, William Barrett

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