Health status in 1040 adults with disorders of sex development (DSD): a European multicenter study

Endocrine Connections
Henrik Falhammardsd-LIFE group

Abstract

The knowledge about health status in adults with disorder of sex development (DSD) is scarce. A cross-sectional observational study in 14 European tertiary centers recruited 1040 participants (717 females, 311 males, 12 others) with DSD. Mean age was 32.4 ± 13.6 year (range 16-75). The cohort was divided into: Turner (n = 301), Klinefelter (n = 224), XY-DSD (n = 222), XX-DSD (excluding congenital adrenal hyperplasia (CAH) and 46,XX males) (n = 21), 46,XX-CAH (n = 226) and 45,X/46,XY (n = 45). Perceived and objective health statuses were measured and compared to European control data. In DSD, fair to very good general health was reported by 91.4% and only 8.6% reported (very) bad general health (controls 94.0% and 6.0%,P < 0.0001). Longstanding health issues other than DSD and feeling limited in daily life were reported in 51.0% and 38.6%, respectively (controls 24.5% and 13.8%,P < 0.0001 both). Any disorder except DSD was present in 84.3% (controls 24.6%,P < 0.0001). Males reported worse health than females. In the subgroup analysis, Klinefelter and 46,XX-DSD patients reported bad general health in 15.7% and 16.7%, respectively (Turner 3.2% and CAH 7.4%). Comorbidities were prevalent in all DSD subgroups but Klinefelter and Tur...Continue Reading

References

Jan 6, 2006·The Journal of Clinical Endocrinology and Metabolism·Anders BojesenClaus H Gravholt
Oct 13, 2006·The Journal of Clinical Endocrinology and Metabolism·Henrik FalhammarMarja Thorén
Sep 20, 2007·The Journal of Clinical Endocrinology and Metabolism·Henrik FalhammarMarja Thorén
Feb 20, 2008·The Lancet Oncology·Minouk J SchoemakerUNKNOWN UK Clinical Cytogenetics Group
Jul 2, 2009·The Journal of Clinical Endocrinology and Metabolism·Louise FrisénAgneta Nordenskjöld
Mar 2, 2010·The Journal of Clinical Endocrinology and Metabolism·Nicole ReischFelix Beuschlein
Aug 20, 2010·The Journal of Clinical Endocrinology and Metabolism·Wiebke ArltUNKNOWN United Kingdom Congenital Adrenal Hyperplasia Adult Study Executive (CaHASE)
Sep 8, 2010·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·S BertelloniS Mora
Oct 15, 2011·European Journal of Pediatrics·Hanan TossonLou Ann Gartner
Dec 14, 2011·European Journal of Endocrinology·Henrik FalhammarMarja Thorén
Jan 10, 2012·Endocrine·Henrik Falhammar, Marja Thorén
Jun 19, 2012·Endocrine Reviews·Kristian H MortensenClaus H Gravholt
Jul 18, 2012·European Journal of Endocrinology·Ingrid NermoenKristian Løvås
Sep 20, 2012·The Journal of Clinical Endocrinology and Metabolism·Gabriela P FinkielstainDeborah P Merke
Nov 3, 2012·The Journal of Clinical Endocrinology and Metabolism·Kristian A GrothAnders Bojesen
Dec 5, 2013·The Journal of Clinical Endocrinology and Metabolism·Henrik FalhammarLouise Frisén
Oct 4, 2014·The Journal of Clinical Endocrinology and Metabolism·Henrik FalhammarAnna Nordenström
Dec 9, 2014·The Journal of Clinical Endocrinology and Metabolism·Evelien E J W SmeetsHedi L Claahsen-van der Grinten
Jun 4, 2015·Endocrinology and Metabolism Clinics of North America·Adina F Turcu, Richard J Auchus
Jul 1, 2015·The Journal of Clinical Endocrinology and Metabolism·Henrik FalhammarAnna Nordenström
Sep 5, 2015·Endocrine·Henrik FalhammarAnna Nordenström
Feb 27, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Henrik Falhammar, David J Torpy
May 21, 2016·Frontiers in Endocrinology·Maria Felicia FaienzaGiacomina Brunetti
Oct 28, 2016·Translational Andrology and Urology·Martin Kathrins, Thomas F Kolon

❮ Previous
Next ❯

Citations

Jun 25, 2019·Psychosomatic Medicine·Annelou L C de VriesUNKNOWN dsd-LIFE Group
Feb 1, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Noha MusaLubna Fawaz
Nov 21, 2019·Journal of the Endocrine Society·Federica BuonocoreJohn C Achermann
Aug 1, 2019·Endocrine Reviews·Amy B WisniewskiBerenice B Mendonca
Sep 10, 2020·Frontiers in Endocrinology·Swetha RangaswamaiahHenrik Falhammar
Oct 10, 2020·PloS One·Amy Rosenwohl-MackJason D Flatt
Nov 11, 2020·BMC Endocrine Disorders·Tania Mayvel Espinosa ReyesHenrik Falhammar
Feb 7, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Junke XiaXiangdong Kong
Mar 21, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Anna NordenströmHenrik Falhammar
Jul 15, 2021·Journal of the Endocrine Society·Xin Li GongUta Neumann
Oct 4, 2021·The Journal of Clinical Endocrinology and Metabolism·Henrik FalhammarAnna Nordenström

❮ Previous
Next ❯

Software Mentioned

R
LIFE
SAS
dsd

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.