PMID: 6142642Jan 1, 1984

Health status of workers with past exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in the manufacture of 2,4,5-trichlorophenoxyacetic acid: comparison of findings with and without chloracne

American Journal of Industrial Medicine
M MosesI J Selikoff


Chloracne was found in 52% of 226 workers in a 1979 cross-sectional survey at a plant where 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) had been manufactured from 1948 to 1969. Mean duration of residual chloracne was 26 years, and in 29 subjects, it had been present for 30 years. A significant increased prevalence of abnormal gamma-glutamyl transpeptidase (GGT) and higher mean GGT were found in those with chloracne, compared to those without. Although mean triglyceride values were higher in those with chloracne, the difference was not statistically significant. Neurological examination showed a statistically significant higher prevalence of abnormal sensory findings in those with chloracne. Increased prevalence of angina and reported myocardial infarction in those with chloracne was not significant when age-adjusted. Increased prevalence of reported sexual dysfunction and decreased libido in those with chloracne compared to those without was statistically significant after age adjustment. No differences were found between those with and without chloracne in serum cholesterol, total urinary porphyrins, or in reproductive outcome.


Apr 1, 1977·European Journal of Clinical Investigation·P BelfrageT Wiebe
Apr 1, 1979·The Journal of Investigative Dermatology·M M BuxmanK A Holbrook
Jan 1, 1978·Toxicology and Applied Pharmacology·E E McConnellD W Dalgard
Jun 1, 1979·British Journal of Haematology·R K WoodruffJ S Tobias
Dec 1, 1979·Journal of the American Dietetic Association
May 1, 1978·Toxicology and Applied Pharmacology·E E McConnellM W Harris
Nov 1, 1978·Toxicology and Applied Pharmacology·R J KocibaC G Humiston
May 1, 1976·Toxicology and Applied Pharmacology·J Q RoseP J Gehring
Jul 1, 1973·British Journal of Industrial Medicine·G May
Sep 1, 1973·Environmental Health Perspectives·B A SchwetzC G Gerbig
Aug 1, 1974·Toxicology and Applied Pharmacology·J G VosJ G Zinkl
Sep 1, 1974·American Industrial Hygiene Association Journal·H B ElkinsH L Smith
Sep 1, 1973·Environmental Health Perspectives·M W HarrisB N Gupta
Sep 1, 1973·Environmental Health Perspectives·B N GuptaB C Bullock
Sep 1, 1973·Environmental Health Perspectives·W B Crummett, R H Stehl
Sep 1, 1973·Environmental Health Perspectives·H G LangerP R Briggs
Aug 1, 1973·Food and Cosmetics Toxicology·J B GreigJ M Barnes
Aug 1, 1971·The Journal of Urology·W F MELICKR E KELLY
Nov 1, 1971·Toxicology and Applied Pharmacology·K D Courtney, J A Moore
May 1, 1982·British Journal of Industrial Medicine·G May
Mar 1, 1981·International Journal of Dermatology·M M Buxman
Jun 1, 1980·Environmental Health Perspectives·J E HuffL Tomatis
Apr 1, 1980·Archives of Toxicology·B Holmstedt
May 1, 1982·American Journal of Epidemiology·J C TownsendR R Cook
Jun 30, 1981·Toxicology and Applied Pharmacology·J M HenckK S Rao
Aug 1, 1980·Toxicology and Applied Pharmacology·J R OlsonR A Neal
Jan 1, 1981·Archives of Environmental Health·J Pazderova-VejlupkováL Jirásek
Dec 1, 1955·The Journal of Urology·W F MELICKE P WHEELER
Jun 1, 1964·Archives of Dermatology·J BLEIBERGI L APPLEBAUM
Apr 15, 1965·The New England Journal of Medicine·L G KOSSR E KELLY


Jun 1, 1993·American Journal of Industrial Medicine·M H SweeneyL B Connally
Jul 1, 1993·American Journal of Industrial Medicine·W N ChengG F Liu
Apr 1, 1994·American Journal of Industrial Medicine·G M CalvertW E Halperin
Jul 1, 1994·Protein Science : a Publication of the Protein Society·A R Mushegian, E V Koonin
Jan 1, 1990·International Archives of Occupational and Environmental Health·A ZoberP Huber
Oct 2, 2001·Neurotoxicology·J E MichalekJ W Albers
Jun 12, 2001·Annals of Epidemiology·J E MichalekM P Longnecker
Mar 1, 1986·Archives of Environmental Health·R E Jones, M Chelsky
Jul 27, 2000·Food Additives and Contaminants·M H Sweeney, P Mocarelli
Jan 30, 2003·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Jessica F GreeneDennis Paustenbach
Dec 13, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·M WeselakW Foster
Oct 1, 1988·British Journal of Industrial Medicine·A M JenningsA M Ward
Jun 6, 1998·Occupational and Environmental Medicine·A C PesatoriP A Bertazzi
Feb 5, 2000·Occupational and Environmental Medicine·J J CollinsS G Riordan
Dec 1, 1995·Environmental Health Perspectives·M M Feeley
Feb 1, 1997·Environmental Health Perspectives·W E DaniellG M Franklin
Jun 25, 1998·Environmental Health Perspectives·D O HryhorczukC Zugerman
May 26, 1998·Environmental Health Perspectives·G M CalvertM A Fingerhut
Jun 1, 1986·Veterinary Immunology and Immunopathology·J M SpitsbergenR E Peterson
May 1, 1991·The Science of the Total Environment·M Gough
Jan 14, 2012·The Journal of Sexual Medicine·Lúcia Alves da Silva LaraAna Carolina Japur de Sá Rosa-e-Silva
Nov 1, 1992·Annals of Epidemiology·J GoldbergW G Henderson
Jul 27, 2015·Journal of the American Academy of Dermatology·Andrew T PattersonDirk M Elston
Aug 1, 1992·Journal of the American Academy of Dermatology·J KershenovichP E LeBoit
Jan 29, 2014·Plastic and Reconstructive Surgery·Mark W ClemensKaren Evans
Oct 6, 2000·Andrologia·S SignoriniP Mocarelli
Aug 14, 2002·Acta Neurologica Scandinavica·F ThömkeH C Hopf
Apr 17, 1986·Nature·A Hay, E K Silbergeld
Dec 12, 1985·Nature·M Gough
May 9, 1985·Nature·A Hay, E K Silbergeld
Jan 1, 1989·American Journal of Industrial Medicine·G AssennatoF Merlo
Jan 1, 1987·American Journal of Industrial Medicine·E K Silbergeld, D R Mattison
Mar 25, 2010·American Journal of Physical Anthropology·Rohina RubiczMichael H Crawford
Jun 13, 2012·Human Nature : an Interdisciplinary Biosocial Perspective·Katherine E Starkweather, Raymond Hames
May 1, 1996·Critical Reviews in Toxicology·S TasD Lison
May 12, 2006·Critical Reviews in Toxicology·E Mariussen, F Fonnum
Nov 1, 1996·Archives of Andrology·R De CelisA Feria-Velasco
Sep 21, 2001·Critical Reviews in Clinical Laboratory Sciences·J B Whitfield

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