Health status response of rheumatoid arthritis to treatment with DAB486IL-2

Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association
J AndersonL W Moreland

Abstract

To examine and compare health status and disease activity changes in patients with rheumatoid arthritis (RA) in a clinical trial of the biologic agent DAB486IL-2. Data on 45 patients with RA who were enrolled in a multicourse, double-blind trial, consisting of a first, placebo-controlled, course followed by open-label treatment with the active agent to a total of 3 active courses, were examined for evidence of improvement in health status (measured using the 5 components of the Arthritis Impact Measurement Scales 2 [AIMS2]) and disease activity (measured using standard clinical measures and erythrocyte sedimentation rate). Over a single course of treatment, DAB486IL-2-treated patients showed significant improvement relative to placebo-treated patients on the symptom and social components of AIMS2 and in patient's assessment of disease activity. With subsequent open-label courses of treatment with DAB486IL-2, all 5 AIMS2 health status components and the disease activity measures of tender and swollen joint counts, grip strength, and the observer and patient assessments showed steady and generally parallel improvement. Short-term health status effects of this biologic agent were detected using the AIMS2.

References

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Citations

Oct 8, 1999·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·X S RenR F Meenan
Nov 18, 2004·Annals of the Rheumatic Diseases·E TaalR P Riemsma
Dec 1, 1999·Annals of the Rheumatic Diseases·D E FurstJ S Smolen
Oct 16, 2001·Rheumatology·G J TijhuisT P Vliet Vlieland

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