Healthcare-associated fungal outbreaks: New and uncommon species, New molecular tools for investigation and prevention

Antimicrobial Resistance and Infection Control
Marie-Elisabeth BougnouxJean-Ralph Zahar

Abstract

Outbreaks of healthcare-associated fungal infections have repeatedly been described over recent years, often caused by new or uncommon species. Candida auris, a recently described multidrug-resistant yeast species, is certainly the most worrisome species having caused several severe healthcare outbreaks of invasive infections, on four continents. Also, large nosocomial outbreaks due to uncommon fungal species such as Exserohilum rostratum and Sarocladium kiliense, were both linked to contamination of medical products, however the source of another outbreak, caused by Saprochaete clavata, remains unresolved. Furthermore, these outbreaks identified new populations under threat in addition to those commonly at risk for invasive fungal infections, such as immunosuppressed and intensive care unit patients. All of these outbreaks have highlighted the usefulness of a high level of awareness, rapid diagnostic methods, and new molecular typing tools such as Whole Genome Sequencing (WGS), prompt investigation and aggressive interventions, including notification of public health agencies. This review summarizes the epidemiological and clinical data of the majority of healthcare-associated outbreaks reported over the last 6 years caused by...Continue Reading

References

Jul 1, 1987·Journal of Clinical Microbiology·E GuéhoS A Meyer
Feb 5, 2011·Emerging Infectious Diseases·David M EngelthalerS Arunmozhi Balajee
Apr 1, 2011·Journal of Clinical Microbiology·Ziauddin KhanRachel Chandy
Jul 1, 2011·Journal of Clinical Microbiology·Wee Gyo LeeHee-Chang Jang
Nov 8, 2012·The New England Journal of Medicine·Marion A KainerUNKNOWN Tennessee Fungal Meningitis Investigation Team
Dec 21, 2012·The New England Journal of Medicine·Rachel M SmithUNKNOWN Multistate Fungal Infection Outbreak Response Team
Jan 8, 2013·Diagnostic Microbiology and Infectious Disease·Aliki IoakimidouNikolaos Malissiovas
Jun 14, 2013·Journal of Clinical Microbiology·Shawn R LockhartMary E Brandt
Sep 10, 2013·Fungal Genetics and Biology : FG & B·David Andes, Arturo Casadevall
Oct 25, 2013·The New England Journal of Medicine·Tom M ChillerUNKNOWN Multistate Fungal Infection Clinical Investigation Team
May 3, 2014·Mycopathologia·Natália MartinsMariana Henriques
Jun 22, 2014·Journal of Clinical Microbiology·Anastasia P LitvintsevaDavid M Engelthaler
May 21, 2015·European Journal of Clinical Investigation·Setareh DavoudiDimitrios P Kontoyiannis
Dec 19, 2015·Disaster Medicine and Public Health Preparedness·Kaja M AbbasKerry J Redican
Feb 20, 2016·Emerging Infectious Diseases·Kizee A EtienneAnastasia P Litvintseva
Feb 26, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Emil P Lesho
Jul 28, 2016·The Journal of Infection·Belinda CalvoArnaldo Lopes Colombo
Sep 17, 2016·The Journal of Hospital Infection·A ChowdharyJ F Meis
Oct 26, 2016·Antimicrobial Resistance and Infection Control·Silke SchelenzMatthew C Fisher
Nov 7, 2016·Infectious Disease Clinics of North America·Geehan Suleyman, George J Alangaden
Nov 25, 2016·Journal of Clinical Microbiology·Masako MizusawaSean X Zhang
Dec 19, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shawn R LockhartAnastasia P Litvintseva
Dec 19, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cornelius J Clancy, M Hong Nguyen
Dec 29, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S VallabhaneniT M Chiller
Jan 19, 2017·Emerging Infectious Diseases·Leighann SherryRiina Rautemaa-Richardson
May 12, 2017·Clinical Microbiology Reviews·Alexandre AlanioStéphane Bretagne
May 19, 2017·MMWR. Morbidity and Mortality Weekly Report·Sharon TsayBrendan R Jackson
Aug 11, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Jennifer L CadnumCurtis J Donskey
Sep 4, 2017·The Journal of Hospital Infection·G MooreC S Brown
Sep 16, 2017·The Journal of Infectious Diseases·Maiken Cavling Arendrup, Thomas F Patterson
Sep 25, 2017·The Journal of Hospital Infection·M BiswalA Chakrabarti
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sharon TsaySnigdha Vallabhaneni
Dec 7, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Emil P LeshoEdward E Walsh

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Citations

Jun 21, 2019·BMC Infectious Diseases·Caroline MasloJennifer Coetzee
Jul 12, 2019·Medical Mycology·Christina C Chang, Stuart M Levitz
Nov 7, 2018·Journal of Intensive Care·Andrea CortegianiAnuradha Chowdhary
Jan 14, 2021·Microorganisms·Tecla CiociolaWalter Magliani
Oct 11, 2020·Mycopathologia·Diego H CaceresFerry Hagen
May 28, 2020·Mycopathologia·Diego H CaceresMark D Lindsley
Aug 8, 2021·Infectious Disease Clinics of North America·Geeta Sood, Trish M Perl
Aug 27, 2021·Journal of Fungi·Hannah M Edwards, Johanna Rhodes

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Methods Mentioned

BETA
genotyping

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