Healthcare Cost and Utilization in Nonalcoholic Fatty Liver Disease: Real-World Data From a Large U.S. Claims Database

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Alina M AllenRozalina G McCoy

Abstract

The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing. The health care burden resulting from the multidisciplinary management of this complex disease is unknown. We assessed the total health care cost and resource utilization associated with a new NAFLD diagnosis, compared with controls with similar comorbidities. We used OptumLabs Data Warehouse, a large national administrative claims database with longitudinal health data of over 100 million individuals enrolled in private and Medicare Advantage health plans. We identified 152,064 adults with a first claim for NAFLD between 2010 and 2014, of which 108,420 were matched 1:1 by age, sex, metabolic comorbidities, length of follow-up, year of diagnosis, race, geographic region, and insurance type to non-NAFLD contemporary controls from the OptumLabs Data Warehouse database. Median follow-up time was 2.6 (range 1-6.5) years. The final study cohort consisted of 216,840 people with median age 55 (range 18-86) years, 53% female, 78% white. The total annual cost of care per NAFLD patient with private insurance was $7,804 (interquartile range [IQR] $3,068-$18,688) for a new diagnosis and $3,789 (IQR $1,176-$10,539) for long-term management. These costs are significant...Continue Reading

References

May 29, 1999·Gastroenterology·C A MatteoniA J McCullough
Jan 3, 2013·JAMA : the Journal of the American Medical Association·Victor R Fuchs
Mar 19, 2014·Journal of Clinical Gastroenterology·Zobair M YounossiAlita Mishra
Apr 29, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Siddharth SinghRohit Loomba
Jul 10, 2014·Health Affairs·Paul J WallaceWilliam H Crown
Sep 6, 2014·Digestive Diseases and Sciences·Andrew P WrightKathleen E Corey
Jun 10, 2015·JAMA : the Journal of the American Medical Association·Mary E Rinella
Jul 15, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Edith M KoehlerHarry L A Janssen
Apr 1, 2016·Population Health Management·Brenna L BradyCharles Ruetsch
Oct 22, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair M YounossiRachel Beckerman
Mar 28, 2017·Journal of Managed Care & Specialty Pharmacy·Jessica WeaverPanagiotis Marvos
Jul 18, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naga ChalasaniArun J Sanyal
Aug 13, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chris EstesArun J Sanyal
Sep 25, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alina M AllenPatrick S Kamath
Dec 7, 2017·Health Affairs·Micah Hartman The National Health Expenditure Accounts Team

❮ Previous
Next ❯

Citations

Aug 3, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair M Younossi
Jan 3, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Melinda H Spooner, Donald B Jump
Oct 24, 2019·Digestive Diseases and Sciences·Margaret MorrisonWing-Kin Syn
Dec 14, 2019·The American Journal of Gastroenterology·Stuart C GordonRobert J Wong
Apr 3, 2020·JAMA Network Open·Grishma HirodeRobert J Wong
Oct 28, 2018·Hormone Molecular Biology and Clinical Investigation·Simonetta LugariAmedeo Lonardo
Feb 19, 2020·Gut·Rohit Loomba, Leon A Adams
Jun 4, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lei LuoYu Chen
May 8, 2019·Hepatology Communications·Naim AlkhouriMazen Noureddin
Feb 23, 2020·PharmacoEconomics·Elliot B Tapper, Jagpreet Chhatwal
Dec 26, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alina M AllenMeng Yin
Jun 4, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alina M AllenRozalina G McCoy
Nov 9, 2019·Hepatology Communications·James M PaikZobair M Younossi
Mar 11, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sarah R LieberAlfred Sidney Barritt
Jan 5, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Heather PattonArthur McCullough
Nov 11, 2020·Journal of Research in Health Sciences·Ammar Salehi-SahlabadiAzita Hekmatdost
Feb 13, 2021·Journal of Clinical Medicine·Amedeo Lonardo
Nov 24, 2020·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Antoni Sicras-MainarSalvador Augustín
Nov 17, 2020·ACG Case Reports Journal·Hirsh D Trivedi
Feb 9, 2021·Hepatology Communications·Joana Vieira Barbosa, Michelle Lai
Sep 15, 2020·Gut and Liver·Soumya MuragDonghee Kim
Apr 25, 2021·Lancet·Elizabeth E PowellMary Rinella
Apr 20, 2021·Clinical Liver Disease·Suraj D SeraiSudha A Anupindi
May 28, 2021·Journal of Hepatology·Peter Jepsen, Zobair M Younossi
Jan 25, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hannes HagströmFredrik Åberg
Jul 5, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Simon C MathewsFrances L Revere
Jan 1, 2022·Hepatology Communications·Joana Vieira BarbosaMichelle Lai
Jan 18, 2022·Journal of Medical Economics·Vinod K RustgiMohamed I Elsaid

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.