Healthcare costs with tiotropium plus usual care versus usual care alone following 1 year of treatment in patients with chronic obstructive pulmonary disorder (COPD)

PharmacoEconomics
Mitchell FriedmanSteven Kesten

Abstract

Healthcare costs for chronic obstructive pulmonary disease (COPD) have continued to increase with the increasing prevalence of the disease. New interventions that can reduce the medical costs of COPD are needed. Tiotropium bromide, a once-daily inhaled anticholinergic, has been evaluated in patients with COPD enrolled in two 1-year randomised, double-blind, placebo-controlled (usual care) trials which showed the drug reduced exacerbations and improved spirometry, dyspnoea, and health status. To retrospectively assess the direct costs of medical care for COPD in a US healthcare setting for patients treated with tiotropium in addition to usual care compared with usual care alone over a 1-year timeframe. The study was based on resource utilisation in the two previously described trials. Resource utilisation and clinical data were prospectively collected for the two 1-year, randomised, double-blind trials of tiotropium plus usual care versus usual care alone (placebo) in 921 patients with COPD. Usual care was defined as any medication for COPD used prior to the trial except anticholinergics and long-acting beta-adrenoceptor agonists. Medical care resource utilisation was recorded at every scheduled visit in each trial. Mean total c...Continue Reading

References

Jun 1, 1992·The American Review of Respiratory Disease·P W JonesP Littlejohns
Apr 1, 1991·Statistics in Medicine·D B Rubin, N Schenker
Aug 1, 1995·American Journal of Respiratory and Critical Care Medicine·S E LapinskyA S Slutsky
Apr 20, 1999·Chest·D A MahlerW H Anderson
Feb 16, 2000·Chest·S D SullivanT A Lee
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·T A SeemungalJ A Wedzicha
Jun 10, 2000·Chest·R E HyattM Schroeder
Jun 10, 2000·Chest·N F Voelkel, R Tuder
Feb 7, 2001·Chest·P MonagleM Andrew
Feb 15, 2001·Chest·S A StrasselsP S Mahajan
Apr 24, 2001·American Journal of Respiratory and Critical Care Medicine·S I RennardK Rickard
Jul 18, 2001·PharmacoEconomics·H S Ruchlin, E J Dasbach
Sep 11, 2001·American Journal of Respiratory and Critical Care Medicine·R DahlUNKNOWN Formoterol in Chronic Obstructive Pulmonary Disease I Study Group
Nov 6, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·S ChodoshT J Witek
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·J A Wedzicha
Feb 28, 2002·The European Respiratory Journal·R CasaburiT Witek
Mar 2, 2002·The European Respiratory Journal·W VinckenUNKNOWN Dutch/Belgian Tiotropium Study Group
Jun 18, 2002·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Kenneth R ChapmanUNKNOWN International study group
Feb 26, 2004·The European Respiratory Journal·J B OostenbrinkW Vincken

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Citations

Jan 1, 2010·ClinicoEconomics and Outcomes Research : CEOR·Shalini NaikThomas J Mattei
Apr 7, 2010·International Journal of Chronic Obstructive Pulmonary Disease·Donald P Tashkin
Aug 31, 2010·PharmacoEconomics·Douglas W MapelJeno P Marton
Oct 14, 2008·Journal of Occupational and Environmental Medicine·Theodore DarkowAmy L Phillips
Jul 28, 2006·Current Medical Research and Opinion·Nikos ManiadakisNikolaos Siafakas
Oct 4, 2007·Journal of the American Geriatrics Society·Eric Kleerup
Apr 20, 2006·Pulmonary Pharmacology & Therapeutics·Gustavo J Rodrigo, Luís J Nannini
Jul 21, 2005·The Annals of Pharmacotherapy·Heather Somand, Tami L Remington
Oct 30, 2008·The Annals of Pharmacotherapy·Andrea M ChenPatrick M Finnegan
Jul 22, 2014·The Cochrane Database of Systematic Reviews·Charlotta KarnerPhillippa Poole
Mar 29, 2014·The Cochrane Database of Systematic Reviews·Kayleigh M KewChristopher J Cates
Jun 20, 2007·British Journal of Community Nursing·Sonia Berjon-Aparicio
Jul 9, 2010·Journal of Medical Economics·Josephine A MauskopfMelissa D Juniper

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