Healthcare Utilization, Costs of Care, and Mortality Among Psatients With Spinal Muscular Atrophy

Journal of Health Economics and Outcomes Research
Hiangkiat TanPerry B Shieh

Abstract

To understand treatment patterns, healthcare resource utilization, and costs of care among patients with spinal muscular atrophy (SMA). Methods: SMA patients were identified from a large managed care population using administrative claims data from January 2006 to March 2016. Patients were classified into infantile, childhood-onset, and late-onset groups based on age of first SMA diagnosis. They were matched 1:1 to non-SMA patients based on age, gender, geography, and health plan type. In the infantile group, 17.4% and 26.1% were treated with invasive and non-invasive ventilation, respectively. Uses of orthotics/orthoses and orthopedic surgery were frequent: 54.5% and 22.7% childhood group; 27.0% and 38.5% late-onset group. Mean per member per month costs in SMA vs. matched non-SMA patients was $25,517 vs. $406 (infantile); $6,357 vs. $188 (childhood-onset); $2,499 vs. $742 (late-onset). SMA patients, particularly with infantile onset, incurred significantly higher healthcare utilization and costs than the general population.

References

Jul 13, 2002·American Journal of Medical Genetics·Shuji OginoRobert B Wilson
Sep 1, 2007·Journal of Child Neurology·Ching H WangUNKNOWN Participants of the International Conference on SMA Standard of Care
Jan 14, 2010·Developmental Neurorehabilitation·Joergen JeppesenJes Rahbek
Nov 4, 2011·Orphanet Journal of Rare Diseases·Adele D'AmicoEnrico Bertini
Jun 5, 2012·The Journal of the American Academy of Orthopaedic Surgeons·Addisu MesfinArabella I Leet
Oct 19, 2012·Neurology·Petra KaufmannUNKNOWN Pediatric Neuromuscular Clinical Research Network for Spinal Muscular Atrophy (PNCR)
Jul 10, 2013·Muscle & Nerve·Jane LarkindaleValerie A Cwik
Oct 28, 2014·Muscle & Nerve·W David ArnoldJohn T Kissel
Nov 22, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michelle A Farrar, Matthew C Kiernan
May 6, 2016·Orphanet Journal of Rare Diseases·Constanze KlugKlaus H Nagels
Jun 7, 2016·Journal of Medical Economics·Edward P ArmstrongNicholas Sicignano
Aug 20, 2017·Orphanet Journal of Rare Diseases·Julio López-BastidaJuan Oliva-Moreno
Nov 18, 2017·Annals of Neurology·Stephen J KolbUNKNOWN NeuroNEXT Clinical Trial Network on behalf of the NN101 SMA Biomarker Investigators
Dec 29, 2018·Pediatric Neurology·Michael LeeMichael L McManus
May 21, 2019·Journal of Market Access & Health Policy·Daniel C MaloneOmar Dabbous

❮ Previous
Next ❯

Citations

Feb 13, 2021·Applied Health Economics and Health Policy·Erik LandfeldtThomas Sejersen
Nov 24, 2020·Journal of Market Access & Health Policy·Lisa BelterJill Jarecki
Jan 22, 2021·Orphanet Journal of Rare Diseases·Alisha MonnetteLizheng Shi
Mar 23, 2021·Journal of Neuromuscular Diseases·H J McMillanH Lochmüller

❮ Previous
Next ❯

Methods Mentioned

BETA
SMA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
B Chabrol, I Desguerre
Neurosciences : the Official Journal of the Pan Arab Union of Neurological Sciences
Abdulaziz Al-Saman, Osama Mudhafar
Fetal and Pediatric Pathology
Tracy Chang, Maria Gieron-Korthals
© 2021 Meta ULC. All rights reserved