Healthy and Pathological Brain Aging: From the Perspective of Oscillations, Functional Connectivity, and Signal Complexity

Neuropsychobiology
Ryouhei IshiiManabu Ikeda

Abstract

Healthy aging is associated with impairment in cognitive information processing. Several neuroimaging methods such as functional magnetic resonance imaging, positron emission tomography and near-infrared spectroscopy have been used to explore healthy and pathological aging by relying on hemodynamic or metabolic changes that occur in response to brain activity. Since electroencephalography (EEG) and magnetoencephalography (MEG) are able to measure neural activity directly with a high temporal resolution of milliseconds, these neurophysiological techniques are particularly important to investigate the dynamics of brain activity underlying neurocognitive aging. It is well known that age is a major risk factor for Alzheimer's disease (AD), and that synaptic dysfunction represents an early sign of this disease associated with hallmark neuropathological findings. However, the neurophysiological mechanisms underlying AD are not fully elucidated. This review addresses healthy and pathological brain aging from a neurophysiological perspective, focusing on oscillatory activity changes during the resting state, event-related potentials and stimulus-induced oscillatory responses during cognitive or motor tasks, functional connectivity betw...Continue Reading

References

Jan 1, 1975·Neuropsychologia·J W Brown, J Jaffe
Jul 1, 1992·Electroencephalography and Clinical Neurophysiology·G Pfurtscheller
Aug 1, 1992·Acta Neurologica Scandinavica·P HartikainenP Riekkinen
Jan 1, 1995·Annual Review of Psychology·J E Birren, L M Fisher
Jun 1, 1997·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·W Klimesch
Oct 21, 1998·Electroencephalography and Clinical Neurophysiology·J Y YordanovaE Başar
Apr 20, 1999·Neuroreport·R IshiiM Takeda
Apr 21, 1999·Brain Research. Brain Research Reviews·W Klimesch
Nov 27, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·G Pfurtscheller, F H Lopes da Silva
Oct 30, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·C Neuper, G Pfurtscheller
Jun 18, 2005·NeuroImage·Daria OsipovaEero Pekkonen
Aug 19, 2005·Human Brain Mapping·Claudio BabiloniPaolo M Rossini
Dec 27, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Claudio BabiloniPaolo M Rossini
Feb 3, 2006·Cerebral Cortex·C J StamPh Scheltens
Mar 28, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Claudio BabiloniPaolo M Rossini
Jul 21, 2006·Neuroscience Letters·Daria OsipovaEero Pekkonen
Sep 18, 2007·Progress in Neurobiology·Paolo M RossiniJohn Polich
Jan 14, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ryouhei IshiiMasatoshi Takeda
Jun 29, 2010·Current Opinion in Neurology·Yong He, Alan Evans
Sep 24, 2010·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Ryouhei IshiiMasatoshi Takeda
Oct 12, 2010·Journal of Alzheimer's Disease : JAD·Claudio BabiloniPaolo M Rossini
Mar 15, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·K NishidaT Kinoshita
Jun 24, 2011·Brain Imaging and Behavior·Vera Maria LeirerIris-Tatjana Kolassa
Sep 20, 2011·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Mateusz GolaAndrzej Wróbel
Mar 13, 2013·Journal of Alzheimer's Disease : JAD·Alberto FernándezStephan Moratti
Apr 6, 2013·IEEE Transactions on Bio-medical Engineering·Toshimitsu MushaTakashi Asada
May 22, 2013·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Mateusz GolaAndrzej Wróbel
Oct 15, 2013·Neurobiology of Aging·Irene van de VijverK Richard Ridderinkhof
Jan 1, 2014·Frontiers in Aging Neuroscience·Natalya PonomarevaEvgeny Rogaev
Jan 11, 2014·Frontiers in Aging Neuroscience·Pilar GarcésAlberto Fernández
Jan 18, 2014·Brain and Cognition·Bruno KoppKarl Wessel
Jan 21, 2014·NeuroImage·Holly E RossiterNick S Ward
Mar 1, 2014·Journal of Alzheimer's Disease : JAD·Fabrizio VecchioPaolo Maria Rossini
May 14, 2014·Journal of Alzheimer's Disease : JAD·Fabrizio VecchioPaolo Maria Rossini

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Citations

Dec 26, 2018·Oxidative Medicine and Cellular Longevity·L A Ramos-ChávezV Pérez de la Cruz
Jan 19, 2020·Journal of Neuro-oncology·Vera BelgersLinda Douw
Mar 3, 2020·Frontiers in Aging Neuroscience·Shane FresnozaAnja Ischebeck
Jan 31, 2019·Frontiers in Human Neuroscience·Greg RuppThomas D Marcotte
Oct 19, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Monique S BoordHannah A D Keage
Dec 29, 2020·Frontiers in Aging Neuroscience·Alisa BergerMichael Doppelmayr
Mar 7, 2021·Neuropsychologia·Gianvito LaeraAlexandra Hering
Mar 27, 2021·Mechanisms of Ageing and Development·Francesca AlùFabrizio Vecchio
Aug 30, 2020·Neuroscience Letters·Wei ZhangCuiping Li
Mar 31, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Andrea GuerraAntonio Suppa
Apr 10, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·John G Semmler, George M Opie
Apr 9, 2021·Frontiers in Aging Neuroscience·Josje M BootsmaTibor Hortobágyi
Jul 21, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yağmur ÖzbekGörsev G Yener
Apr 15, 2020·NeuroImage·Bikash SahooDipanjan Roy
Sep 9, 2021·Cerebral Cortex·John D LewisJeanne Townsend
Sep 21, 2021·Frontiers in Aging Neuroscience·Jonathan A Zegarra-ValdiviaAngel Nuñez
Apr 11, 2020·NeuroImage·Dinavahi V P S MurtySupratim Ray

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