Healthy Lifestyle Is Associated With Reduced Mortality in Patients With Inflammatory Bowel Diseases.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Chun-Han LoAshwin N Ananthakrishnan

Abstract

It is not clear whether a healthy lifestyle affects mortality of patients with inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). We collected data form the Nurses' Health Study (1986-2014), Nurses' Health Study II (1991-2015), and Health Professionals Follow-up Study (1986-2014), which assess lifestyles with serial questionnaires. We estimated joint and individual associations between 5 healthy lifestyle factors after IBD diagnosis (never smoking, body mass index 18.5-24.9 kg/m2, vigorous physical activity in the highest 50% with non-zero value, alternate Mediterranean diet score ≥4, and light drinking [0.1-5.0 g/d]) and mortality using Cox proportional hazards models. We documented 83 deaths in 363 patients with CD during 4741 person-years and 80 deaths in 465 patients with UC during 6061 person-years. The median age of IBD diagnosis was 55 y. Compared to patients with IBD with no healthy lifestyle factors, patients with IBD with 3-5 healthy lifestyle factors had a significant reduction in all-cause mortality (hazard ratio [HR], 0.29; 95% CI, 0.16-0.52; Ptrend < .0001). This reduction was significant in patients with CD (Ptrend = .003) as well as in patients with UC (Ptrend = .0003)...Continue Reading

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Citations

Jun 26, 2020·United European Gastroenterology Journal·Wolfgang Alexander SeegerAxel Dignass
Jan 17, 2021·Nutrients·Charlotte M VerburgtJohan E Van Limbergen
May 12, 2020·Gastroenterology·Chun-Han LoAshwin N Ananthakrishnan
Aug 14, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Rintaro MoroiAtsushi Masamune
Oct 5, 2021·Inflammatory Bowel Diseases·Maitreyi RamanJeff Vallance

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