Healthy Lung Vessel Morphology Derived From Thoracic Computed Tomography

Frontiers in Physiology
Michael PiennZoltán Bálint

Abstract

Knowledge of the lung vessel morphology in healthy subjects is necessary to improve our understanding about the functional network of the lung and to recognize pathologic deviations beyond the normal inter-subject variation. Established values of normal lung morphology have been derived from necropsy material of only very few subjects. In order to determine morphologic readouts from a large number of healthy subjects, computed tomography pulmonary angiography (CTPA) datasets, negative for pulmonary embolism, and other thoracic pathologies, were analyzed using a fully-automatic, in-house developed artery/vein separation algorithm. The number, volume, and tortuosity of the vessels in a diameter range between 2 and 10 mm were determined. Visual inspection of all datasets was used to exclude subjects with poor image quality or inadequate artery/vein separation from the analysis. Validation of the algorithm was performed manually by a radiologist on randomly selected subjects. In 123 subjects (men/women: 55/68), aged 59 ± 17 years, the median overlap between visual inspection and fully-automatic segmentation was 94.6% (69.2-99.9%). The median number of vessel segments in the ranges of 8-10, 6-8, 4-6, and 2-4 mm diameter was 9, 34, 1...Continue Reading

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Citations

Jul 4, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Melody DongJeffrey A Feinstein
Apr 8, 2021·Biomedical Signal Processing and Control·Andreia S GaudêncioJoão M Cardoso

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Methods Mentioned

BETA
X-ray

Software Mentioned

GraphPad Prism
GraphPad
SPSS

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