Hearing ability with age in northern European women: a new web-based approach to genetic studies.

PloS One
Lisa E WolberFrances M K Williams

Abstract

Age-related hearing impairment (ARHI) affects 25-40% of individuals over the age of 65. Despite the high prevalence of this complex trait, ARHI is still poorly understood. We hypothesized that variance in hearing ability with age is largely determined by genetic factors. We collected audiologic data on females of Northern European ancestry and compared different audiogram representations. A web-based speech-to-noise ratio (SNR) hearing test was compared with pure-tone thresholds to see if we could determine accurately hearing ability on people at home and the genetic contribution to each trait compared. Volunteers were recruited from the TwinsUK cohort. Hearing ability was determined using pure-tone audiometry and a web-based hearing test. Different audiogram presentations were compared for age-correlation and reflection of audiogram shape. Using structural equation modelling based on the classical twin model the heritability of ARHI, as measured by the different phenotypes, was estimated and shared variance between the web-based SNR test and pure-tone audiometry determined using bivariate modelling. Pure-tone audiometric data was collected on 1033 older females (age: 41-86). 1970 volunteers (males and females, age: 18-85) part...Continue Reading

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Citations

Jul 26, 2014·Human Molecular Genetics·Lisa E WolberFrances M K Williams
Jun 18, 2015·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Sukhleen K MomiFrances M K Williams
Jan 29, 2020·Journal of Neuroscience Research·Helena Rose Rees WellsFrances M K Williams
Oct 28, 2019·Scientific Reports·Andries Paul NagtegaalAndré Goedegebure
Mar 24, 2020·European Journal of Human Genetics : EJHG·Stacey S ChernyFrances M K Williams
Jul 8, 2020·Journal of Medical Genetics·Suzanne E de BruijnUNKNOWN DOOFNL Consortium
Jul 19, 2020·Gene Therapy·Zhen ZhangFeng Liu
Jan 14, 2020·Hearing Research·Neil J InghamKaren P Steel

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