Hearing disorders in multiple sclerosis

Handbook of Clinical Neurology
M Furst, R A Levine

Abstract

Multiple sclerosis (MS) is a disease that is both a focal inflammatory and a chronic neurodegenerative disease. The focal inflammatory component is characterized by destruction of central nervous system myelin, including the spinal cord; as such it can impair any central neural system, including the auditory system. While on the one hand auditory complaints in MS patients are rare compared to other senses, such as vision and proprioception, on the other hand auditory tests of precise neural timing are never "silent." Whenever focal MS lesions are detected involving the pontine auditory pathway, auditory tests requiring precise neural timing are always abnormal, while auditory functions not requiring such precise timing are often normal. Azimuth sound localization is accomplished by comparing the timing and loudness of the sound at the two ears. Hence tests of azimuth sound localization must obligatorily involve the central nervous system and particularly the brainstem. Whenever a focal lesion was localized to the pontine auditory pathway, timing tests were always abnormal, but loudness tests were not. Moreover, a timing test that included only high-frequency sounds was very often abnormal, even when there was no detectable foca...Continue Reading

Citations

Jul 4, 2016·Journal of Neurology·Chris J D HardyJason D Warren
Oct 19, 2016·Journal of Neuroscience Research·Dylan Verden, Wendy B Macklin
Sep 20, 2017·Developmental Neurobiology·Patrick LongGabriel Corfas
Sep 14, 2018·Journal of Immunology Research·Massimo RalliMarco de Vincentiis
Nov 1, 2020·Nature Communications·Sharlen MooreKlaus-Armin Nave
Feb 10, 2021·Developmental Neurobiology·David C KohrmanGabriel Corfas

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