Hearing evaluation in two sisters with a T8993G point mutation of mitochondrial DNA

International Journal of Pediatric Otorhinolaryngology
Yuki SakaiJunko Miyamoto

Abstract

We report on two sisters with a T8993G point mutation of mitochondrial DNA, and their hearing evaluation. Considering auditory function, hearing in the elder sister remains almost normal. However, in the younger sister, the auditory brainstem response (ABR) threshold has fluctuated remarkably during a 3-year follow-up. The threshold changes of ABR in the younger sister suggest that her hearing problems may well be caused by both cochlear nerves and retrocochlear lesions. Our experience is clinically important because there have been only a few reports on hearing evaluation in patients with a T8993G point mutation of mitochondrial DNA.

References

Apr 1, 1987·Acta Paediatrica Japonica; Overseas Edition·M KagaK Nihei
Sep 5, 1995·Biochemical and Biophysical Research Communications·M NakamuraJ Kimura
Dec 1, 1993·Annals of Neurology·F M SantorelliS DiMauro
Mar 7, 1998·American Journal of Human Genetics·N Fischel-Ghodsian

❮ Previous
Next ❯

Citations

Apr 20, 2018·Frontiers in Physiology·Alain DautantRoza Kucharczyk

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.