Hearing function after betahistine therapy in patients with Ménière's disease

Brazilian Journal of Otorhinolaryngology
Seyed Javad Seyed TootoonchiDaniel Fadaei Fouladi

Abstract

Preventing or reversing hearing loss is challenging in Ménière's disease. Betahistine, as a histamine agonist, has been tried in controlling vertigo in patients with Ménière's disease, but its effectiveness on hearing problems is not known. To examine the effect of betahistine on hearing function in not-previously-treated patients with Ménière's disease and to define possible contributors in this regard. A total of 200 not-previously-treated patients with definite unilateral Ménière's disease received betahistine by mouth (initial dose, 16mg three times a day; maintenance dose, 24-48mg daily in divided doses). Changes in indicators of hearing status before and six months after treatment were documented. Hearing loss was considered as the mean hearing level >25dB HL at five frequencies. The mean duration of disease was 3.37 years. Six months after treatment the mean hearing level decreased by 6.35dB compared to that at the baseline (p<0.001). Both patients' age and the duration of disease correlated negatively with the improvement in hearing function. Post treatment hearing loss was independently associated with age, the initial hearing level and the chronicity of disease. The corresponding optimal cut-off points for predicating...Continue Reading

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Citations

Aug 9, 2016·The Laryngoscope·Mahyar EtminanBruce C Carleton
Jan 16, 2019·Journal of Molecular Neuroscience : MN·Shuxia QianXiaoling Zhang
Nov 4, 2017·Medwave·Andrés Rosenbaum, Matías Winter

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