Hearing loss with semicircular canal transection and Pseudomonas aeruginosa otitis media

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Angela R PrevattPatrick J Antonelli

Abstract

To determine if Pseudomonas aeruginosa (PA) otitis media (OM) increases the risk of sensorineural hearing loss (SNHL) with semicircular canal transection in the guinea pig model. PA was injected transtympanically into both middle ears of pigmented guinea pigs. Saline-injected animals served as controls. Two to 4 days after injection, one horizontal semicircular canal was transected and sealed. Hearing was tested using electrocochleography before and after transection. PA-OM was induced in all PA-injected ears. Five days after semicircular canal transection, click-evoked thresholds were significantly elevated in ears with PA-OM (P = 0.00009) but not in saline-injected ears (P = 0.398). Violation of the inner ear in the presence of PA-OM is associated with increased risk of SNHL in the guinea pig. Factors unique to PA infection may be responsible for SNHL with labyrinthine injury in humans with chronic otitis media.

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Citations

Jan 27, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Sarah E ShefelbinePatrick J Antonelli
May 19, 2012·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Paulo Henrique WeckwerthMarco Antonio Húngaro Duarte
Oct 13, 2009·The Laryngoscope·Tyler C GrindalPatrick J Antonelli
Dec 10, 2003·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael T FalconePatrick J Antonelli
Jun 10, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·James C LeePatrick J Antonelli
Jun 23, 2012·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Snezana Dragoljub JesicBorivoj Bogdan Babic

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