Hearing outcome of infants with congenital cytomegalovirus and hearing impairment

Archives of Disease in Childhood
Efraim BilavskyJacob Amir

Abstract

Congenital cytomegalovirus (cCMV) is the most common non-genetic cause of childhood sensorineural hearing loss. Antiviral treatment has been shown to prevent hearing deterioration in these infants. However, studies focused on infants with hearing impairment at birth and on the specific degree of impairment and further improvement or deterioration are lacking. To investigate the relationship between hearing status at birth and any change in hearing status at the end of a prolonged follow-up period, after receiving 12 months of antiviral treatment in children born with hearing impairment due to congenital cCMV. Clinical, laboratory, radiological and audiological data of all infants with cCMV infection followed in our centre between 2005 and 2013 were reviewed. Treatment with antiviral medication for hearing impairment found during the neonatal period was12 months of gan/valganciclovir. Hearing studies were performed only on infants who had been followed up for more than 1 year after treatment. Hearing impairment at birth was found in 54 (36.2%) of the 149 infants diagnosed with symptomatic cCMV, and found in 77 affected ears; unilateral in 31 (57.4%) and bilateral in 23 (42.6%). After 1 year of antiviral treatment and a long-term...Continue Reading

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Citations

Dec 23, 2016·Clinical Pediatrics·Efraim BilavskyJacob Amir
Nov 16, 2017·The Pediatric Infectious Disease Journal·Suzanne E LuckUNKNOWN ESPID Congenital CMV Group Meeting, Leipzig 2015
Aug 2, 2017·The Pediatric Infectious Disease Journal·Einat ShmueliEfraim Bilavsky
May 5, 2017·Archives of Disease in Childhood. Fetal and Neonatal Edition·Daphne Ari-Even RothGalia Barkai
Nov 20, 2018·Antiviral Chemistry & Chemotherapy·Ashwaq A AbdullahMohd-Azmi Mohd-Lila
Apr 21, 2018·The Pediatric Infectious Disease Journal·Liron ZivEfraim Bilavsky
Jan 14, 2020·European Journal of Pediatrics·Lev DorfmanEfraim Bilavsky
Apr 12, 2017·Birth Defects Research·Nicole L DavisAthena P Kourtis
Dec 21, 2016·Journal of the Association for Research in Otolaryngology : JARO·Mattia CarraroRobert V Harrison
Jul 25, 2018·Journal of Neonatal-perinatal Medicine·Matilde CicciaFabrizio Sandri
Oct 7, 2020·Microorganisms·Giulia ChioprisSusanna Esposito
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