Hearing preservation at low frequencies by insulin-like growth factor 1 in a guinea pig model of cochlear implantation

Hearing Research
Kohei YamaharaNorio Yamamoto

Abstract

The hybrid or electric-acoustic stimulation cochlear implant is indicated in patients with a residual hearing at low frequencies. It provides electric and acoustic stimulation for compensating for high- and low-frequency sounds, respectively. However, the implantation procedure damages the cochlea, resulting in loss of the residual-hearing and diminished effects of the acoustic-hearing in several patients. To prevent hearing loss after implantation, corticosteroids have been used clinically although their effects are limited. As an alternative to corticosteroids, insulin-like growth factor 1 (IGF1) has shown potent effects in various types of cochlear injury. In this study, the effects of IGF1 on hearing preservation were examined after cochlear implantation to a normal-hearing guinea pig model. The electrode was inserted in an atraumatic way through the round window membrane of guinea pigs with the application of a gelatin-sponge soaked with IGF1 or saline. The auditory brainstem response (ABR) was recorded pre-operatively, immediately after cochlear implantation, and 7, 14, 28, and 56 days after electrode insertion. In comparison to the control group, the IGF1-treated group showed better hearing preservation at low frequencie...Continue Reading

Citations

Aug 17, 2020·Current Opinion in Otolaryngology & Head and Neck Surgery·Li Gao, Takayuki Nakagawa
Jan 1, 2020·Laryngoscope Investigative Otolaryngology·Megan J FoggiaMarlan R Hansen
Jul 22, 2020·Journal of the Association for Research in Otolaryngology : JARO·Donald L SwiderskiBryan E Pfingst
Nov 3, 2020·Frontiers in Cellular Neuroscience·Li GaoTakayuki Nakagawa
Jun 14, 2021·Otolaryngologic Clinics of North America·Steven A Gordon, Richard K Gurgel
Aug 7, 2021·Current Opinion in Otolaryngology & Head and Neck Surgery·Osama TarabichiMarlan R Hansen

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