Abstract
Adrenergic regulation of the heart function is well documented by many studies. Catecholamines act through alpha(1)-, beta(1)-, beta(2)-, and beta(3)-adrenoceptors (ARs) in the heart. There are many findings about the changes of beta(1)- and beta(2)-AR in heart failure (HF). On the other hand, the role of other AR subtypes is not clear yet. We focused on determining how HF could affect gene expression and specific ligand binding to alpha(1A)-, alpha(1B)-, alpha(1D)-, beta(1)-, beta(2)-, and beta(3)-AR. Hearts from 11 patients with HF subjected to transplantation were investigated. As a control, corresponding parts from hearts not suitable for transplantation were used. We have found significantly higher mRNA levels of alpha(1A)-, alpha(1B)-,beta(1)-, and beta(2)-AR in the left ventricle of failing hearts compared to the levels in controls. beta(3)-AR mRNA levels in the left ventricle of failing hearts were not changed. No changes in mRNA levels of all receptors studied in other cardiac areas were found. On the other hand, binding studies showed a substantial decrease in left ventricles of failing hearts in all alpha(1)-AR subtypes and in beta(1)- and beta(2)-AR. However, the binding to beta(3)-AR was not changed. Our results su...Continue Reading
References
Oct 1, 1995·Cardiovascular Research·O E BroddeH R Zerkowski
Dec 1, 1995·Cardiovascular Research·Q ChangR S Conway
Jan 1, 1997·Hypertension·M J MorrisM D Esler
Jun 1, 1997·Naunyn-Schmiedeberg's Archives of Pharmacology·A J Kaumann, P Molenaar
Jan 15, 1998·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·H G Zimmer
Mar 29, 2001·Circulation·S MoniotteJ L Balligand
May 10, 2001·Journal of Molecular and Cellular Cardiology·J D Port, M R Bristow
Nov 15, 2003·Circulation Research·Martin J LohseThomas Eschenhagen
Jan 3, 2006·Trends in Cardiovascular Medicine·Roland JahnsMartin J Lohse
Jan 24, 2006·Life Sciences·Jaromír MyslivecekRichard Kvetnanský
Feb 17, 2006·Pharmacology & Therapeutics·Bertrand Rozec, Chantal Gauthier
Apr 14, 2006·Journal of Pharmacological Sciences·Otto-Erich BroddeKirsten Leineweber
Jul 29, 2006·International Journal of Cardiology·Roland JahnsMartin J Lohse
Sep 26, 2006·Biochemical and Biophysical Research Communications·Sahoko IchiharaMitsunori Iwase
Jan 20, 2007·Circulation Research·Jerald CurranThomas R Shannon
May 22, 2007·Stress : the International Journal on the Biology of Stress·O KrizanovaL Kubovcakova
Jul 25, 2007·Clinical and Experimental Pharmacology & Physiology·Elizabeth A Woodcock
Jan 16, 2008·Sub-cellular Biochemistry·E G Kranias, D M Bers
Citations
Sep 22, 2015·PloS One·Artur Junio Togneri FerronAna Paula Lima-Leopoldo
Dec 13, 2017·PloS One·Ashley N GuilloryCeleste C Finnerty
Nov 8, 2020·Cells·Gizem Kaykı-MutluEbru Arioglu-Inan
Feb 9, 2017·Journal of Cardiovascular Pharmacology·Alessandro Cannavo, Walter J Koch
Jun 3, 2021·International Journal of Molecular Sciences·Dianne M Perez
Jun 12, 2021·Frontiers in Cell and Developmental Biology·Dianne M Perez