Heart adrenoceptor gene expression and binding sites in the human failing heart

Annals of the New York Academy of Sciences
Viliam FischerJaromir Myslivecek

Abstract

Adrenergic regulation of the heart function is well documented by many studies. Catecholamines act through alpha(1)-, beta(1)-, beta(2)-, and beta(3)-adrenoceptors (ARs) in the heart. There are many findings about the changes of beta(1)- and beta(2)-AR in heart failure (HF). On the other hand, the role of other AR subtypes is not clear yet. We focused on determining how HF could affect gene expression and specific ligand binding to alpha(1A)-, alpha(1B)-, alpha(1D)-, beta(1)-, beta(2)-, and beta(3)-AR. Hearts from 11 patients with HF subjected to transplantation were investigated. As a control, corresponding parts from hearts not suitable for transplantation were used. We have found significantly higher mRNA levels of alpha(1A)-, alpha(1B)-,beta(1)-, and beta(2)-AR in the left ventricle of failing hearts compared to the levels in controls. beta(3)-AR mRNA levels in the left ventricle of failing hearts were not changed. No changes in mRNA levels of all receptors studied in other cardiac areas were found. On the other hand, binding studies showed a substantial decrease in left ventricles of failing hearts in all alpha(1)-AR subtypes and in beta(1)- and beta(2)-AR. However, the binding to beta(3)-AR was not changed. Our results su...Continue Reading

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Citations

Dec 13, 2017·PloS One·Ashley N GuilloryCeleste C Finnerty
Feb 9, 2017·Journal of Cardiovascular Pharmacology·Alessandro Cannavo, Walter J Koch
Jun 3, 2021·International Journal of Molecular Sciences·Dianne M Perez
Jun 12, 2021·Frontiers in Cell and Developmental Biology·Dianne M Perez

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