Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus.

PloS One
Gustavo PalaciosW Ian Lipkin

Abstract

Atlantic salmon (Salmo salar L.) mariculture has been associated with epidemics of infectious diseases that threaten not only local production, but also wild fish coming into close proximity to marine pens and fish escaping from them. Heart and skeletal muscle inflammation (HSMI) is a frequently fatal disease of farmed Atlantic salmon. First recognized in one farm in Norway in 1999, HSMI was subsequently implicated in outbreaks in other farms in Norway and the United Kingdom. Although pathology and disease transmission studies indicated an infectious basis, efforts to identify an agent were unsuccessful. Here we provide evidence that HSMI is associated with infection with piscine reovirus (PRV). PRV is a novel reovirus identified by unbiased high throughput DNA sequencing and a bioinformatics program focused on nucleotide frequency as well as sequence alignment and motif analyses. Formal implication of PRV in HSMI will require isolation in cell culture and fulfillment of Koch's postulates, or prevention or modification of disease through use of specific drugs or vaccines. Nonetheless, as our data indicate that a causal relationship is plausible, measures must be taken to control PRV not only because it threatens domestic salmon...Continue Reading

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Citations

Apr 4, 2014·Veterinary Research·Oystein Wessel FinstadEspen Rimstad
Apr 11, 2014·Virus Research·Sebastien MassartThierry Candresse
Sep 9, 2010·MBio·Vladimir Trifonov, Raul Rabadan
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May 16, 2012·Diseases of Aquatic Organisms·Marie LøvollTorstein Tengs
Jun 23, 2012·Antiviral Research·Frederick S B KibengeMolly J T Kibenge
Jan 9, 2016·Veterinary Research·Hanne Merethe HaatveitEspen Rimstad
Oct 18, 2011·Current Opinion in Virology·Linlin Li, Eric Delwart
Oct 15, 2013·Journal of Fish Diseases·H D RodgerN M Ruane
Jun 10, 2015·Fish & Shellfish Immunology·Maria Krudtaa DahleAleksei Krasnov
Aug 2, 2015·Diagnostic Microbiology and Infectious Disease·Dagmara W LewandowskaMichael Huber
Sep 11, 2012·Preventive Veterinary Medicine·Anja B KristoffersenPeder A Jansen
Apr 19, 2015·Veterinary Research·Øystein WesselMaria Krudtaa Dahle
May 8, 2016·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Maureen K PurcellPaul K Hershberger

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Datasets Mentioned

BETA
GU994013-GU994022

Methods Mentioned

BETA
PCR
biopsies
PCRs

Software Mentioned

FASD
TopPred
Coffee
Frequency Analysis of Sequence Data ( FASD
StatView
ClustalX
Tracer
FASTX
MEGA
ICTV

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