Heart-directed autoimmunity: the case of rheumatic fever

Journal of Autoimmunity
L GuilhermeJ Kalil

Abstract

Molecular mimicry was proposed as a potential mechanism for streptococcal sequelae leading to rheumatic fever (RF) and rheumatic heart disease (RHD). CD4(+)infiltrating T cells are able to recognize streptococcal M peptides and heart tissue proteins. We analyzed the M5 peptide- and heart-specific responses, cytokine profile and T cell receptor (TCR) BV usage from peripheral and heart-infiltrating T cell lines and clones from patients across the clinical spectrum of ARF/RHD. The patient with ARF displayed a higher frequency of mitral valve infiltrating T cell clones reactive against M5: 1-25, 81-103 and 163-177 regions and several valve-derived proteins than the post-RF and chronic RHD patient (67%; 20% and 27%, respectively). The presence of oligoclonal BV families indicative of oligoclonal T cell expansion among mitral valve-derived T cell lines was increased in the chronic RHD patient. Furthermore, mitral valve T cell lines from all patients produced significant amounts of inflammatory cytokines interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNFalpha) in response to M5(81-96) peptide, with the highest production attained by the chronic RHD patient. These data are consistent with an important role for M5 peptid...Continue Reading

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Citations

Jan 5, 2007·Journal of Gastroenterology and Hepatology·Gianpaolo BragagniGiorgio Zoli
Jan 19, 2010·Human Immunology·Karen C TorresAntonio L Teixeira
Sep 18, 2007·Journal of Ethnopharmacology·Jianlin HuangJieruo Gu
Jul 20, 2007·Scandinavian Journal of Immunology·L GuilhermeJ Kalil
Jul 19, 2013·Human Vaccines & Immunotherapeutics·Michael F GoodManisha Pandey
Sep 25, 2018·Fetal and Pediatric Pathology·Maheshkumar PoomarimuthuJayalakshmi Mariakuttikan
Mar 5, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Antonio L TeixeiraFrancisco Cardoso
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nadia M J EllisMadeleine W Cunningham
Dec 18, 2020·Autoimmunity Reviews·Leanne M DooleyMichael Kotiw

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