Heart Disease and the Liver: Pathologic Evaluation

Gastroenterology Clinics of North America
Anne Knoll Koehne de Gonzalez, J H Lefkowitch

Abstract

Liver injury due to acute and chronic heart failure has long been recognized. This article discusses the concepts of acute cardiogenic liver injury (ACLI) and cardiac or congestive hepatopathy (CH) along with their clinical manifestations and sequelae. Histologically, ACLI manifests as centrilobular hepatocellular necrosis, whereas CH is associated with centrilobular hepatocyte atrophy, dilated sinusoids, and perisinusoidal fibrosis, progressing to bridging fibrosis and ultimately cirrhosis. ACLI is associated with marked increases in aminotransferase levels, whereas CH is associated with a cholestatic pattern of laboratory tests. Certain cardiac medications have also been implicated as a cause of liver fibrosis.

Citations

Nov 18, 2017·Abdominal Radiology·Michael L Wells, Sudhakar K Venkatesh
Apr 6, 2019·The American Journal of Surgical Pathology·Dustin E BoschMatthew M Yeh
Aug 19, 2020·Pediatric Radiology·Jonathan R DillmanAdam M Lubert
May 13, 2019·Internal and Emergency Medicine·Piero Portincasa
Dec 17, 2020·International Journal of Molecular Sciences·José Ignacio ForteaEmilio Fábrega
Sep 22, 2020·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Chun-Hong XieFang-Qi Gong
May 3, 2021·ESC Heart Failure·Pieter van der BijlJeroen J Bax
Jun 19, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nilum RajoraRamesh Saxena

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