Heart Disease in Adults With Down Syndrome Between 1996 and 2016.

Journal of the American Board of Family Medicine : JABFM
Veronica FitzpatrickBrian Chicoine

Abstract

To describe demographic factors and calculate prevalence of heart disease-related conditions among the adult Down syndrome (DS) sample population and to compare demographic and heart disease-related conditions between the DS sample population (n = 2342) and the general population. Using a retrospective, descriptive cohort study design, analyses were based on 20 years of data collected on the Adult Down Syndrome Center patient population. Prevalence of heart disease, stroke, and associated risk conditions are reported as counts (%) with corresponding odds ratio (OR) indicating odds of diagnosis among the DS sample compared with the general population. Corresponding Pearson c2 P-values were calculated to represent statistically significant differences between prevalence of diagnoses in the DS sample compared with the general population. In cases where prevalence was low, Fisher's Exact Test P-value were calculated. Adults with DS had lower odds of diagnosis of heart disease and most associated risk conditions, specifically coronary heart disease (OR = 0.0537, P < .0001), heart failure (OR = 0.6353, P = .0091), hypertension (OR = 0.0325, P < .0001), diabetes (OR = 0.4840, P < .0001), and high total cholesterol (OR = 0.2086, P < .0...Continue Reading

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