Heart failure and left ventricular remodeling after reperfused acute myocardial infarction in patients with hypertension

Hypertension
Guido ParodiD Antoniucci

Abstract

In the thrombolytic era, hypertension has been shown to adversely affect the development of heart failure after acute myocardial infarction (AMI). We sought to examine the relation between antecedent hypertension and heart failure after mechanical reperfusion and to test the impact of postinfarction left ventricular remodeling on heart failure in hypertensive patients. A series of 953 patients (324 hypertensives) with AMI treated with successful primary percutaneous coronary intervention underwent a 5-year follow-up. A subgroup of 325 subjects underwent 2D echocardiography at admission, 1 month, and 6 months. From day 1 to 6 months, despite similar improvement in regional and global left ventricular function and similar 6-month infarct artery patency rate, left ventricular end-diastolic volume increased in the normotensives (122+/-36 mL to 131+/-47 mL; P<0.001) but not in the hypertensives (127+/-41 mL to 128+/-31 mL; P=0.768). At 6 months, the incidence of left ventricular remodeling in hypertensive and normotensive patients was not different (22% versus 28%; P=0.210). However, at 5 years, the incidences of hospitalization for heart failure (7% versus 3%; P=0.014) and of New York Heart Association functional class > or =2 (53%...Continue Reading

References

Oct 1, 1992·Journal of Hypertension·J HerlitzA Hjalmarson
Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerI Schnittger
Nov 1, 1988·Journal of the American College of Cardiology·S E NolanH F Weisman
May 30, 1996·The American Journal of Cardiology·I S Blaufarb, E H Sonnenblick
Jan 1, 1996·American Journal of Hypertension·J HerlitzB W Karlson
Aug 26, 1998·European Heart Journal·J S Alpert
Sep 12, 2000·Current Cardiology Reports·C Y Hart, M M Redfield
Jan 4, 2001·The New England Journal of Medicine·S K GandhiW C Little
Jan 4, 2001·The New England Journal of Medicine·R S Vasan, E J Benjamin
Mar 30, 2002·Journal of the American College of Cardiology·A Mark RichardsJohn Turner
Nov 7, 2002·JAMA : the Journal of the American Medical Association·Dalane W KitzmanKathryn P Stewart
Mar 14, 2003·The American Journal of Cardiology·Hasan JilaihawiUNKNOWN Healing and Early Afterload Reducing Therapy Trial Investigators

❮ Previous
Next ❯

Citations

Mar 25, 2010·Circulation. Cardiovascular Interventions·Kazuhisa KondoToyoaki Murohara
Feb 10, 2012·Journal of Cardiovascular Medicine·Roberto PedrinelliUNKNOWN Gruppo di Studio Ipertensione e Cuore, Societa’ Italiana di Cardiologia
Aug 22, 2006·Expert Opinion on Biological Therapy·Harald C Ott, Doris A Taylor
Sep 4, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Niels Holmark AndersenSteen Hvitfeldt Poulsen
Dec 23, 2006·Progress in Cardiovascular Diseases·Gilles W De Keulenaer, Dirk L Brutsaert
Dec 22, 2010·American Heart Journal·Guido Parodi, David Antoniucci
Dec 9, 2008·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Lene A RustadAsbjørn Støylen
Nov 29, 2014·American Journal of Hypertension·Jin Sup ParkUNKNOWN Korea Working Group on Myocardial Infarction Investigators
Dec 29, 2018·The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology·Islam BastawyWael El Kilany

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.