Heart failure and sleep-disordered breathing

Current Opinion in Cardiology
Alexander B ZhaiHaissam Haddad

Abstract

Sleep-disordered breathing, which includes both obstructive and central sleep apnoea (OSA and CSA, respectively), is highly prevalent in patients with heart failure. In this review, we outline our current understanding of the bidirectional relationship between these disorders and heart failure. We also explore the role of recent advances in therapeutics. Although early studies suggest promise of adaptive servoventilation in treating sleep-disordered breathing, particularly CSA with associated Cheyne-Stokes respiration, the recent clinical trial in the heart failure patient population has demonstrated worse cardiovascular outcome in symptomatic patients. Both OSA and CSA are highly prevalent in patients with heart failure. Effective treatment of OSA with continuous positive airway pressure can improve cardiovascular outcome in these patients. However, recent evidence suggests that adaptive servoventilation cannot be safely recommended as a therapy for CSA in the context of heart failure, as a result of increased risk of cardiovascular mortality.

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Citations

Jan 17, 2017·Current Opinion in Cardiology·Alexander B Zhai, Haissam Haddad
Jul 29, 2016·Current Opinion in Cardiology·Michael A GrandnerDaniel Combs
Aug 27, 2021·Frontiers in Medicine·Corrado PelaiaAngela Sciacqua

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