Heart failure elevates serum levels of cibenzoline in arrhythmic patients

Circulation Journal : Official Journal of the Japanese Circulation Society
Takeshi KotakeHideki Morishita

Abstract

Cibenzoline dosing is generally based on renal function, but serum concentrations might be greater than the expected therapeutic levels when standard oral dosing is used. Because heart failure might modify cibenzoline pharmacokinetics, the difference in cibenzoline pharmacokinetics between patients with and without heart failure was evaluated. The study enrolled 368 patients (233 men, 135 women) that had been hospitalized and received cibenzoline therapy at the National Cardiovascular Center from January 2001 to May 2005. There were 89 patients with heart failure (51 men, 38 women) and 279 patients without heart failure (182 men, 97 women). They had therapeutic drug monitoring > or = 3 days after the beginning of treatment with cibenzoline. Brain natriuretic peptide (BNP) was measured in 81 patients (50 men, 31 women) concurrently with therapeutic drug monitoring of cibenzoline. The difference in serum cibenzoline concentration/(dose/weight) (C/D) values between patients with and without heart failure was analyzed using analysis of covariance (ANCOVA) with creatinine clearance (Ccr) serving as the covariate. The effects of dose/weight and the log-transformed BNP (log-BNP) values on serum cibenzoline concentrations were also ass...Continue Reading

References

Nov 1, 1976·Clinical Pharmacokinetics·N L Benowitz, W Meister
Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Jun 1, 1992·The Annals of Thoracic Surgery·O H FrazierK A Dasse
Feb 1, 1990·Journal of Cardiovascular Pharmacology·M CazesP Duchêne-Marullaz
Jan 31, 1986·The American Journal of Cardiology·R L WoosleyD M Roden
Mar 1, 1988·Clinical Pharmacology and Therapeutics·J W MassarellaM S Chow
Mar 1, 1987·Journal of Clinical Pharmacology·J W MassarellaD Keefe
Jul 1, 1984·Journal of Clinical Pharmacology·K C KhooR K Brazzell
Nov 1, 1984·Clinical Pharmacology and Therapeutics·R K BrazzellJ Hannigan
Apr 1, 1984·Antimicrobial Agents and Chemotherapy·G R MatzkeW F Keane
Jan 1, 1983·European Journal of Clinical Pharmacology·M CanalA Dufour
Apr 8, 1983·Journal of Chromatography·M R HackmanM A Brooks
Jul 30, 1999·American Heart Journal·M S WeinfeldL W Stevenson
Feb 7, 2002·European Journal of Clinical Pharmacology·M Takada, M Shibakawa
Feb 19, 2002·The Annals of Pharmacotherapy·Kazuyuki UenoMasahiko Shibakawa
Apr 18, 2002·European Journal of Heart Failure·A Peter MaxwellD Paul Nicholls
Jan 27, 2004·The Annals of Pharmacotherapy·Paul A Arpino, Robert K Hallisey
May 1, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Nobuyuki ShibaUNKNOWN CHART Investigators
Oct 2, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Chika KonishiHiroaki Matsubara
Jan 22, 2005·Journal of Clinical Pharmacy and Therapeutics·M TakadaM Shibakawa

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Citations

Sep 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Kyoichi WadaTakeshi Nakatani

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