Heart Failure Impairs Muscle Blood Flow and Endurance Exercise Tolerance in COPD

COPD
Mayron F OliveiraJ Alberto Neder

Abstract

Heart failure, a prevalent and disabling co-morbidity of COPD, may impair cardiac output and muscle blood flow thereby contributing to exercise intolerance. To investigate the role of impaired central and peripheral hemodynamics in limiting exercise tolerance in COPD-heart failure overlap, cycle ergometer exercise tests at 20% and 80% peak work rate were performed by overlap (FEV1 = 56.9 ± 15.9% predicted, ejection fraction = 32.5 ± 6.9%; N = 16), FEV1-matched COPD (N = 16), ejection fraction-matched heart failure patients (N = 15) and controls (N = 12). Differences (Δ) in cardiac output (impedance cardiography) and vastus lateralis blood flow (indocyanine green) and deoxygenation (near-infrared spectroscopy) between work rates were expressed relative to concurrent changes in muscle metabolic demands (ΔO2 uptake). Overlap patients had approximately 30% lower endurance exercise tolerance than COPD and heart failure (p < 0.05). ΔBlood flow was closely proportional to Δcardiac output in all groups (r = 0.89-0.98; p < 0.01). Overlap showed the largest impairments in Δcardiac output/ΔO2 uptake and Δblood flow/ΔO2 uptake (p < 0.05). Systemic arterial oxygenation, however, was preserved in overlap compared to COPD. Blunted limb perfus...Continue Reading

References

Apr 1, 1988·Sports Medicine·M A Van Baak
Apr 16, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W M KueblerA E Goetz
Mar 7, 2002·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Russell T Hepple
Mar 4, 2003·Journal of Applied Physiology·Bruno GrassiPaolo Cerretelli
Aug 9, 2005·European Journal of Applied Physiology·A AlivertiP T Macklem
Mar 15, 2006·European Journal of Heart Failure·Frans H RuttenArno W Hoes
Oct 11, 2007·Chest·Thomas E Dolmage, Roger S Goldstein
Sep 8, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Priscila Abreu SperandioJ Alberto Neder
May 7, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Markus AmannJerome A Dempsey
May 12, 2010·The Journal of Physiology·Thomas P OlsonBruce D Johnson
May 15, 2010·Journal of Applied Physiology·Stephen J BaileyAndrew M Jones
Mar 18, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ioannis VogiatzisSpyros Zakynthinos
Nov 22, 2011·American Journal of Physiology. Heart and Circulatory Physiology·David C PooleTimothy I Musch
Jul 24, 2012·American Journal of Respiratory and Critical Care Medicine·Philippe GagnonFrançois Maltais
Aug 4, 2012·Journal of Cardiac Failure·Gülmisal GüderStefan Störk
Aug 11, 2012·American Journal of Respiratory and Critical Care Medicine·Jørgen VestboRoberto Rodriguez-Roisin
Oct 2, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Priscila A SperandioJ Alberto Neder
Apr 27, 2013·Journal of Applied Physiology·Ioannis Vogiatzis, Spyros Zakynthinos
Dec 7, 2013·The European Respiratory Journal·Casey E CiavagliaDenis E O'Donnell
Feb 11, 2014·Clinics in Chest Medicine·Denis E O'DonnellJ Alberto Neder
Feb 11, 2014·Clinics in Chest Medicine·Gourab ChoudhuryWilliam MacNee
Mar 1, 1993·The European Respiratory Journal·P H QuanjerJ C Yernault
Mar 5, 2014·European Respiratory Review : an Official Journal of the European Respiratory Society·Frits M E Franssen, Carolyn L Rochester
Jul 2, 2014·Current Heart Failure Reports·Gülmisal Güder, Frans H Rutten
Sep 12, 2014·International Journal of Chronic Obstructive Pulmonary Disease·Miranda Caroline Smith, Jeremy P Wrobel

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Citations

May 14, 2016·COPD·Flavio F ArbexJ Alberto Neder
Oct 25, 2016·International Journal of Cardiology·Alcides RochaJ Alberto Neder
Oct 21, 2016·International Journal of Cardiology·Rafael MesquitaMartijn A Spruit
Jul 1, 2017·American Journal of Respiratory and Critical Care Medicine·Alcides RochaJ Alberto Neder
Feb 16, 2019·The European Respiratory Journal·Alcides RochaJ Alberto Neder
Aug 3, 2020·Current Opinion in Supportive and Palliative Care·J Alberto Neder, Denis E O'Donnell
Apr 20, 2019·The European Respiratory Journal·Emiel F M Wouters
Jan 4, 2020·Sleep & Breathing = Schlaf & Atmung·Luiz Carlos Soares de Carvalho JuniorAudrey Borghi-Silva
Feb 23, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A MazzucoA Borghi-Silva
Oct 20, 2020·Journal of Cardiopulmonary Rehabilitation and Prevention·Adriana MazzucoAudrey Borghi-Silva
Dec 2, 2020·Annals of the American Thoracic Society·J Alberto Neder
Nov 15, 2020·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Zach RozenbaumYan Topilsky
Feb 12, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Polliana B Dos SantosAudrey Borghi-Silva
Feb 20, 2021·Chronic Respiratory Disease·Melissa MilesDmitry Rozenberg

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