PMID: 9538931Apr 16, 1998Paper

Heart failure: is there an energy deficit contributing to contractile dysfunction?

Basic Research in Cardiology
A M Vogt, W Kübler

Abstract

Alterations in myocardial energy metabolism have been demonstrated in both animal experiments and clinical observations. Whether these changes contribute to heart failure has been a longstanding and controversial issue. I. The creatine kinase (CK) system and the high energy phosphates under physiological conditions and in acute heart failure: 1. According to in vivo and in vitro experiments the myocardial creatine/creatine phosphate (Cr/CP) system is directly linked to mitochondrial oxidative phosphorylation via the mitochondrial CK. 2. The shift in the mass action ratio of the CK reaction with increasing myocardial oxygen consumption enables marked stimulation of mitochondrial respiratory function via the Cr/CP system with almost maintained free energy of the adenosine triphosphate/adenosine diphosphate (ATP/ADP) system. 3. In acute heart failure the depressed myocardial content mainly of CP can be considered as an adaptive mechanism related to increased oxygen demands. II. The CK system and the high energy phosphates in chronic heart failure: 1. The alterations observed in the CK system in chronic heart failure cannot be interpreted in terms of an "energy deficit" (i.e., the excess of what is spent over what is received on en...Continue Reading

Citations

Jun 15, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·J HademH Drexler
Jul 5, 2006·Heart Failure Reviews·Marc L AllardMichael J Sole
Apr 18, 2003·Archives of Medical Research·Karla Carvajal, Rafael Moreno-Sánchez
Nov 5, 2002·European Journal of Heart Failure·Cornelia PiperAndrea Dörner
Mar 30, 2007·Journal of Endocrinological Investigation·Z XuG Liu
Jun 17, 2014·Journal of Diabetes and Metabolic Disorders·Md Ashraful Alam, Md Mahbubur Rahman
Jan 3, 2001·Journal of Molecular and Cellular Cardiology·P S BrookesP G Anderson
Aug 11, 2006·Canadian Journal of Physiology and Pharmacology·L Manju, R Renuka Nair
Jul 30, 2009·Pharmacology & Therapeutics·Adarsh KumarVarun Mohan
May 10, 2008·Free Radical Biology & Medicine·Martyna ElasStefan Chlopicki
Mar 2, 2005·Pharmacology & Therapeutics·Masahiko Hoshijima
Jul 19, 2016·Pharmacological Reports : PR·Jerzy JankowskiAnna Jabłecka
Jan 11, 2000·Circulation Research·C H GelbandM K Raizada
Nov 21, 2000·Current Opinion in Clinical Nutrition and Metabolic Care·M J Sole, K N Jeejeebhoy
May 1, 2020·Journal of Clinical Medicine·Anna Di LorenzoFrancesco Giallauria
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·L DaiP G Anderson
Jun 14, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mohan R K DasuJ Regino Perez-Polo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.