Abstract
Several hospital-based investigations have reported that a high proportion of patients with heart failure (HF) have preserved left ventricular ejection fraction (LVEF). The purpose of this study was to determine the prevalence, prognosis, and predictors for mortality of Japanese HF patients with preserved versus reduced LVEF in a prospective cohort fashion. Our hospital-based database including inpatients and also outpatients was used for analysis. Out of 4255 new patients, 597 patients (male/female 414/183, age 65.1+/-12.9 years) were diagnosed as having symptomatic HF at the initial visit. Among 589 HF patients undergoing echocardiography, 398 (67.6%) showed a preserved LVEF (>50%) and 191 (32.4%) had a reduced LVEF (< or =50%). Patients with preserved LVEF were older (p=0.004) and more likely to be female (p=0.002). During follow-up of an average 539 days, 34 cardiovascular deaths occurred, and patients with preserved LVEF showed a better prognosis than those with reduced LVEF (3.2% vs. 7.4% per year, p=0.0097). Multivariate Cox hazards analysis identified LVEF as an independent predictor in all HF patients. Also, separated group analysis showed that presence of chronic kidney disease was independently associated with poor p...Continue Reading
References
May 1, 1997·Journal of Internal Medicine·M KupariR Tilvis
Jul 15, 1997·Circulation·T TsutamotoM Kinoshita
Nov 24, 1998·Circulation·M SenniM M Redfield
Mar 31, 2000·European Heart Journal·A Cohen-SolalG Hanania
Sep 19, 2000·Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology·R Latini, S Masson
Nov 14, 2000·The American Journal of Cardiology·R B DevereuxB V Howard
Aug 29, 2001·The American Journal of Cardiology·H TsutsuiA Takeshita
May 10, 2002·Clinical Cardiology·Qahtan MalkiSyed Jafri
Oct 16, 2002·Annals of Internal Medicine·John S GottdienerTeri A Manolio
Jan 9, 2003·JAMA : the Journal of the American Medical Association·Margaret M RedfieldRichard J Rodeheffer
Jan 22, 2003·Journal of the American College of Cardiology·Frederick A MasoudiHarlan M Krumholz
May 3, 2003·European Heart Journal·Finn GustafssonUNKNOWN DIAMOND Study Group
May 14, 2003·Journal of the American College of Cardiology·Grace L SmithHarlan M Krumholz
Jul 16, 2003·Annals of Internal Medicine·Andrew S LeveyUNKNOWN National Kidney Foundation
Aug 23, 2003·Journal of the American College of Cardiology·Jeptha P CurtisHarlan M Krumholz
Jun 24, 2004·Circulation·Inder AnandPaul B J Burton
Dec 7, 2005·Circulation·Scott D SolomonUNKNOWN Candesartan in Heart Failure Reduction in Mortality (CHARM) Investigators
Jun 7, 2006·Circulation·Alan S GoMichael G Shlipak
Jul 21, 2006·The New England Journal of Medicine·Theophilus E OwanMargaret M Redfield
Jul 21, 2006·The New England Journal of Medicine·R Sacha BhatiaPeter P Liu
Mar 27, 2007·Clinical and Experimental Nephrology·Enyu ImaiSeiichi Matsuo
Jan 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Nobuyuki ShibaHiroaki Shimokawa
Aug 30, 2008·International Heart Journal·Mahmoud M RamadanYoshifusa Aizawa
Nov 26, 2008·Journal of cardiology·Yoshihiro SeoKazutaka Aonuma
Aug 1, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Miyuki Tsuchihashi-MakayaUNKNOWN JCARE-CARD Investigators
Citations
Sep 10, 2014·European Journal of Internal Medicine·María Esther Guisado EsparteroManuel Montero-Perez-Barquero
Jan 5, 2016·European Journal of Heart Failure·Evelien E S van RietFrans H Rutten
Jun 15, 2011·Medicina clínica·Raúl Quirós LópezEmilio Perea Milla
Mar 6, 2015·International Heart Journal·Hidehiro KanekoTakeshi Yamashita
May 8, 2014·Journal of cardiology·Hidehiro KanekoTakeshi Yamashita
Jun 5, 2013·Journal of cardiology·Hidehiro KanekoTakeshi Yamashita
Feb 20, 2013·Journal of cardiology·Masunori MatsuzakiHiroyuki Tsutsui
Jul 24, 2012·Journal of cardiology·Daisuke KutsuzawaIsao Kubota
Mar 17, 2012·Journal of cardiology·Hidehiro KanekoTakeshi Yamashita
Mar 27, 2012·Journal of cardiology·Naoko KatoRyozo Nagai
Oct 4, 2011·Journal of cardiology·Nobukazu IshizakaKazuhiko Koike
Oct 23, 2012·Journal of cardiology·Shinya SuzukiTakeshi Yamashita
Jan 24, 2012·Journal of cardiology·Hajime SatomuraShin-ichi Momomura
Dec 24, 2010·Journal of cardiology·Michinari NakamuraUNKNOWN Shinken Database Study Group
Dec 15, 2010·Blood Pressure·Johannes Soma
Jan 5, 2019·Journal of Hematology & Oncology·Kamal ChamounJorge Cortes
Oct 12, 2019·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Theodora NikolaidouAndrew L Clark