Heart failure with preserved versus reduced left ventricular systolic function: a prospective cohort of Shinken Database 2004-2005

Journal of cardiology
Ayumi GodaTadanori Aizawa

Abstract

Several hospital-based investigations have reported that a high proportion of patients with heart failure (HF) have preserved left ventricular ejection fraction (LVEF). The purpose of this study was to determine the prevalence, prognosis, and predictors for mortality of Japanese HF patients with preserved versus reduced LVEF in a prospective cohort fashion. Our hospital-based database including inpatients and also outpatients was used for analysis. Out of 4255 new patients, 597 patients (male/female 414/183, age 65.1+/-12.9 years) were diagnosed as having symptomatic HF at the initial visit. Among 589 HF patients undergoing echocardiography, 398 (67.6%) showed a preserved LVEF (>50%) and 191 (32.4%) had a reduced LVEF (< or =50%). Patients with preserved LVEF were older (p=0.004) and more likely to be female (p=0.002). During follow-up of an average 539 days, 34 cardiovascular deaths occurred, and patients with preserved LVEF showed a better prognosis than those with reduced LVEF (3.2% vs. 7.4% per year, p=0.0097). Multivariate Cox hazards analysis identified LVEF as an independent predictor in all HF patients. Also, separated group analysis showed that presence of chronic kidney disease was independently associated with poor p...Continue Reading

References

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Citations

Sep 10, 2014·European Journal of Internal Medicine·María Esther Guisado EsparteroManuel Montero-Perez-Barquero
Jun 15, 2011·Medicina clínica·Raúl Quirós LópezEmilio Perea Milla
Mar 6, 2015·International Heart Journal·Hidehiro KanekoTakeshi Yamashita
Jul 24, 2012·Journal of cardiology·Daisuke KutsuzawaIsao Kubota
Dec 24, 2010·Journal of cardiology·Michinari NakamuraUNKNOWN Shinken Database Study Group
Oct 12, 2019·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Theodora NikolaidouAndrew L Clark

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