Heart, kidney, and intestine have different tolerances for anemia

Translational Research : the Journal of Laboratory and Clinical Medicine
Jasper van BommelCan Ince

Abstract

Organ systems do not respond uniformly to changes in systemic oxygen delivery because of global and local redistributive mechanisms. We hypothesized that progressive hemodilution would evoke a different response in the microvascular oxygenation of the heart compared with kidney and gut. To evaluate this hypothesis, we studied the effect of stepwise isovolemic hemodilution on systemic hemodynamic and oxygenation parameters as well as the relation between systemic hematocrit (Ht) and microvascular PO(2) (microPO(2)) in heart, kidney, and intestines in an anesthetized and mechanically ventilated rat model. Baseline conditions were similar in the hemodilution group and in the control group. In the hemodilution group, Ht was diminished from 46.6 +/- 3.8% to 7.0 +/- 1.8% [mean +/- standard deviation (SD)]. This group had no effect on measured hemodynamics; only when Ht fell below 10% did blood pressure start to decrease. The microPO(2) values in heart, kidney, and intestines did not respond uniformly. Renal microPO(2) (56 +/- 10 mm Hg at baseline) started to decrease at a Ht of 38.5 +/- 8.6%, whereas intestinal microPO(2) (59 +/- 6 mm Hg at baseline) did not start to decrease until Ht reached 17.4 +/- 7.1%. Finally, cardiac microPO(2...Continue Reading

References

Dec 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S M Cain, C K Chapler
Feb 1, 1992·Journal of Applied Physiology·E C Van WoerkensP D Verdouw
Jun 1, 1991·Journal of Applied Physiology·D F WilsonM Delivoria-Papadopoulos
Dec 1, 1990·The American Journal of Physiology·H J SchurekU Heckmann
Jan 1, 1986·Canadian Journal of Physiology and Pharmacology·C K Chapler, S M Cain
Jul 1, 1995·Anesthesia and Analgesia·D N DossP A Murray
Jul 1, 1996·British Journal of Anaesthesia·C J LoteC O Savage
Nov 1, 1996·Journal of Applied Physiology·M Sinaasappel, C Ince
Jul 17, 1998·The Journal of Laboratory and Clinical Medicine·B MathesonE Bucci
Jan 30, 1999·British Journal of Anaesthesia·P Van der LindenJ L Vincent
Feb 26, 2000·Cardiovascular Research·C J ZuurbierC Ince
Jan 1, 1961·The American Journal of Physiology·M N LEVY, E S IMPERIAL
Nov 2, 2006·American Journal of Physiology. Renal Physiology·Tanja JohannesCan Ince

❮ Previous
Next ❯

Citations

Jan 18, 2014·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Gregory M T Hare
Apr 18, 2013·Best Practice & Research. Clinical Anaesthesiology·Gregory M T HareAryeh Shander
Feb 28, 2009·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Gregory M T HareC David Mazer
May 5, 2009·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Anya T McLarenGregory M T Hare
Jun 1, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Albert K Y TsuiGregory M T Hare
Dec 22, 2011·British Journal of Anaesthesia·A ShanderG M T Hare
Apr 4, 2009·Critical Care Clinics·Aryeh Shander, Lawrence Tim Goodnough
Nov 22, 2012·Clinical and Experimental Pharmacology & Physiology·Roger G EvansBruce S Gardiner
Jun 6, 2015·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Eun Sil LeeIm Soon Lee
Jan 22, 2015·Revista española de anestesiología y reanimación·R Casans FrancésUNKNOWN Grupo Español de Rehabilitación Multimodal GERM/ERAS-Spain
Oct 8, 2009·Anesthesiology·Tenille E RagoonananGregory M T Hare
Dec 19, 2016·Transfusion·Malte KrömkerJens Meier
Jan 18, 2017·Journal of Diabetes Investigation·Yosuke HirakawaMasaomi Nangaku
Jan 20, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nikhil MistryGregory M T Hare
Nov 4, 2017·Anesthesia and Analgesia·Huaiwu HeCan Ince
Apr 25, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Albert K Y TsuiGregory M T Hare
Jan 6, 2016·Critical Care : the Official Journal of the Critical Care Forum·Can Ince
Jun 13, 2015·Journal of Applied Physiology·Can Ince, Egbert G Mik
Feb 26, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger G Evans
Dec 21, 2016·Critical Care : the Official Journal of the Critical Care Forum·Lara ZafraniCan Ince
Sep 29, 2019·Kidney Research and Clinical Practice·Tomoko HondaMasaomi Nangaku
Sep 4, 2020·Cell Stress & Chaperones·Yifan Chen, Tianzheng Yu
Jan 1, 2015·Khirurgiia·Yu P OrlovG A Baytugaeva
Apr 24, 2021·Free Radical Biology & Medicine·Romain CarcyDidier F Pisani
Nov 23, 2018·The Journal of Surgical Research·Indra Naemi WaackJohanna Katharina Teloh
Nov 12, 2020·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Tina Tomic MahecicJens Meier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Albert K-Y TsuiGregory M T Hare
Proceedings of the National Academy of Sciences of the United States of America
Albert K-Y TsuiGregory M T Hare
British Journal of Anaesthesia
A ShanderGregory M T Hare
© 2021 Meta ULC. All rights reserved