Heart-lung transplantation: successful therapy for patients with pulmonary vascular disease

The New England Journal of Medicine
B A ReitzN E Shumway

Abstract

We report our initial experience with three patients who received heart-lung transplants. The primary immunosuppressive agent used was cyclosporin A, although conventional drugs were also administered. In the first patient, a 45-year-old woman with primary pulmonary hypertension, acute rejection of the transplant was diagnosed 10 and 25 days after surgery but was treated successfully; this patient still had normal exercise tolerance 10 months late. The second patient, a 30-year-old man, underwent transplantation for Eisenmenger's syndrome due to atrial and ventricular septal defects. His graft was not rejected, and his condition was markedly improved eight months after surgery. The third patient, a 29-year-old woman with transposition of the great vessels and associated defects, died four days postoperatively of renal, hepatic, and pulmonary complications. We attribute our success to experience with heart-lung transplantation in primates, to the use of cyclosporin A, and to the anatomic and physiologic advantages of combined heart-lung replacement. We hope that such transplants may ultimately provide an improved outlook for selected terminally ill patients with pulmonary vascular disease and certain other intractable cardiopulm...Continue Reading

References

Mar 10, 1979·Lancet·S W JamiesonN E Shumway
May 1, 1977·The Annals of Thoracic Surgery·L H Toledo-PereyraJ S Najarian
Apr 1, 1978·The Surgical Clinics of North America·F J Veith
Sep 1, 1979·Current Problems in Surgery·W A BaumgartnerN E Shumway
Jun 1, 1970·The Annals of Thoracic Surgery·C R Wildevuur, J R Benfield
Aug 1, 1973·The Annals of Thoracic Surgery·F J VeithM L Gliedman
Jan 1, 1973·Annals of Surgery·S S SieglemanF J Veith
Jul 1, 1969·The Annals of Thoracic Surgery·D A CooleyR D Leachman
Jan 29, 1970·The New England Journal of Medicine·P M StevensD E Jenkins
Jun 1, 1970·The Annals of Thoracic Surgery·F J Veith
Jul 1, 1981·The Journal of Surgical Research·B A ReitzN E Shumway
Oct 1, 1980·Chest·J M NelemsH Vellend
Jul 30, 1981·The New England Journal of Medicine·T E StarzlG P Schröter

❮ Previous
Next ❯

Citations

Jan 1, 1997·Pediatric Pulmonology·B E NoyesD M Orenstein
Nov 1, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Myung H ParkMandeep R Mehra
Jun 30, 2000·Clinical Cardiology·R C Robbins
Jan 1, 1983·Pediatric Cardiology·T A English
Jan 1, 1985·Lung·J R Michael, W R Summer
Jun 12, 2012·Pediatric Cardiology·Don HayesTimothy M Hoffman
Jun 1, 2000·World Journal of Surgery·T E Starzl
Feb 21, 2013·Surgery Today·Yoshiki SawaMeinoshin Okumura
Nov 10, 2012·General Thoracic and Cardiovascular Surgery·Masaaki Sato
Nov 30, 2000·Current Treatment Options in Cardiovascular Medicine·S Rich
Sep 30, 2008·Clinical Reviews in Allergy & Immunology·Marlyn S Woo
Apr 1, 1984·The American Journal of Medicine·S Rich, P S Levy
Dec 1, 1995·The Annals of Thoracic Surgery·H ReichenspurnerB A Reitz
Jan 1, 1986·International Journal of Immunopharmacology·O H NielsenJ Elmgreen
Apr 8, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Stephan KoromWalter Weder
Mar 26, 2004·Transplantation Proceedings·D A HesselinkW Weimar
Mar 26, 2004·Transplantation Proceedings·N R Banner, M H Yacoub
Jan 1, 1987·The Annals of Thoracic Surgery·J G Copeland
Mar 1, 1997·The Annals of Thoracic Surgery·E P ChenP Van Trigt
Nov 20, 1997·Transplantation Proceedings·T BirsanW Klepetko
Jun 18, 1999·Transplantation Proceedings·D AravotB Vidne
Oct 10, 2001·Clinics in Chest Medicine·A P Fishman
Aug 10, 2000·Journal of the American College of Cardiology·G E CookeC V Leier
Aug 26, 1998·Journal of the American College of Cardiology·R LamichJ Narula
Oct 16, 1999·Journal of the American College of Cardiology·N NagayaT Kunieda
May 16, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·R A BleasdaleN R Banner
Oct 25, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·S N MitrukaG J Burckart
Nov 15, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·John V ConteJonathan B Orens
May 5, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·T BîrsanW Klepetko
Apr 15, 1999·Clinical Transplantation·A H TirokeA Haverich
Aug 9, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J J LiPuma
Oct 6, 1983·The New England Journal of Medicine·UNKNOWN Canadian Multicentre Transplant Study Group
Nov 29, 1984·The New England Journal of Medicine·W G Austen, A B Cosimi
May 1, 1986·The New England Journal of Medicine·F J Veith
May 20, 1993·The New England Journal of Medicine·S E Weinberger
Feb 1, 1996·The New England Journal of Medicine·R J BarstUNKNOWN Primary Pulmonary Hypertension Study Group
Jan 4, 2012·British Journal of Anaesthesia·C J E Watson, J H Dark
Oct 1, 1991·Annals of Surgery·R M BolmanM I Hertz
Sep 1, 1993·Annals of Surgery·B P GriffithI Paradis
May 1, 1996·Annals of Surgery·P Van TrigtR M Ungerleider
Sep 24, 1999·Annals of Surgery·B F MeyersG A Patterson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved