Abstract
Heart rate (HR) is an emerging risk factor in coronary artery disease (CAD). However, there is little contemporary data regarding HR and the use of HR-lowering medications, particularly beta-blockers, among patients with stable CAD in routine clinical practice. The goal of the present analysis was to describe HR in such patients, overall and in relation to beta-blocker use, and to describe the determinants of HR. CLARIFY is an international, prospective, observational, longitudinal registry of outpatients with stable CAD, defined as prior myocardial infarction or revascularization procedure, evidence of coronary stenosis of >50%, or chest pain associated with proven myocardial ischemia. A total of 33,438 patients from 45 countries in Europe, the Americas, Africa, Middle East, and Asia/Pacific were enrolled between November 2009 and July 2010. Most of the 33,177 patients included in this analysis were men (77.5%). Mean (SD) age was 64.2 (10.5) years, HR by pulse was 68.3 (10.6) bpm, and by electrocardiogram was 67.2 (11.4) bpm. Overall, 44.0% had HR ≥ 70 bpm. Beta-blockers were used in 75.1% of patients and another 14.4% had intolerance or contraindications to beta-blocker therapy. Among 24,910 patients on beta-blockers, 41.1% h...Continue Reading
References
May 1, 1976·Progress in Cardiovascular Diseases·J P Clausen
Mar 11, 1990·The American Journal of Cardiology·A HjalmarsonJ Ross
May 3, 1997·Lancet·C J Murray, A D Lopez
Jun 1, 1999·JAMA : the Journal of the American Medical Association·P A HeidenreichM A Hlatky
Jun 11, 1999·Journal of the American College of Cardiology·R J GibbonsS C Smith
Jun 25, 1999·BMJ : British Medical Journal·N FreemantleJ Harrison
Feb 20, 2003·Circulation·Jeffrey S BorerUNKNOWN Ivabradine Investigators Group
Jan 11, 2005·Lancet·Peter M Rothwell
Mar 19, 2005·European Heart Journal·Ariel DiazJean-Claude Tardif
Oct 11, 2005·European Heart Journal·Jean-Claude TardifUNKNOWN INITIATIVE Investigators
Jun 1, 2006·European Heart Journal·Kim FoxUNKNOWN ESC Committee for Practice Guidelines (CPG)
Jan 11, 2007·Archives of Internal Medicine·Philippe Gabriel StegUNKNOWN GRACE Investigators
Jan 19, 2007·The New England Journal of Medicine·Gerard F Anderson, Edward Chu
Aug 28, 2007·Journal of the American College of Cardiology·Kim FoxUNKNOWN Heart Rate Working Group
Nov 14, 2007·Circulation·Theodore D FrakerUNKNOWN American College of Cardiology/American Heart Association Task Force on Practice Guidelines Writing Group
Dec 7, 2007·Journal of the American College of Cardiology·Theodore D FrakerClyde W Yancy
Apr 1, 2008·European Heart Journal·Rainer KollochCarl J Pepine
Sep 2, 2008·Lancet·Kim FoxUNKNOWN BEAUTIFUL Investigators
Sep 2, 2008·Lancet·Kim FoxUNKNOWN BEAUTIFUL investigators
Sep 19, 2008·European Heart Journal·Kenneth DicksteinUNKNOWN ESC Committee for Practice Guidelines (CPG)
Oct 2, 2008·European Journal of Heart Failure·Kenneth DicksteinUNKNOWN ESC Committee for Practice Guidelines (CPG)
Jan 13, 2009·European Heart Journal·Jean-Claude TardifUNKNOWN ASSOCIATE Study Investigators
Feb 6, 2009·BMJ : British Medical Journal·Judith HsiaUNKNOWN Women's Health Initiative Research Group
Sep 2, 2009·European Heart Journal·Kim FoxUNKNOWN BEAUTIFUL Investigators
Mar 30, 2010·The American Journal of Cardiology·Jennifer E HoDavid D Waters
Apr 1, 2010·Postgraduate Medical Journal·Caroline A DalyUNKNOWN Euro Heart Survey Investigators
Aug 19, 2010·Circulation. Cardiovascular Quality and Outcomes·Alan J BagnallUNKNOWN Canadian Acute Coronary Syndromes Registry II Investigators
Aug 31, 2010·Lancet·Michael BöhmUNKNOWN SHIFT Investigators
Oct 12, 2010·European Heart Journal·Matteo AnselminoUNKNOWN Euro Heart Survey Investigators
Aug 25, 2011·European Heart Journal·M Louisa AntoniJeroen J Bax
Apr 4, 2013·Nephron. Clinical Practice·Myung-Jin ChoiJa-Ryong Koo
Dec 21, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Eva M LonnMichael Böhm
Citations
Jun 21, 2014·International Journal of Biological Sciences·Donald J Vander GriendJohn T Isaacs
Jun 24, 2014·Revista Española De Cardiología·José L ZamoranoNicola Greenlaw
Jul 23, 2014·PloS One·Paul R KalraUNKNOWN CLARIFY Investigators
Oct 30, 2012·Current Treatment Options in Cardiovascular Medicine·Kelly Axsom, Sripal Bangalore
Aug 28, 2012·European Heart Journal·Ph Gabriel StegUNKNOWN CLARIFY Registry Investigators
Jan 10, 2014·Current Medical Research and Opinion·Zhanna KobalavaUNKNOWN ATHENA trial investigators
Sep 7, 2014·Experimental Gerontology·Ursula Müller-WerdanUNKNOWN ADDITIONS Study Investigators
Jul 15, 2015·Journal of the Chinese Medical Association : JCMA·Sen-Wei TsaiChih-Tai Ting
Nov 19, 2013·The Canadian Journal of Cardiology·Sumeet GandhiUNKNOWN Prospective Observational Longitudinal Registry of Patients With Stable Coronary Artery Disease CLARIFY Registry Investigato
Sep 20, 2015·European Heart Journal·Kim FoxUNKNOWN SIGNIFY investigators
Aug 26, 2014·European Journal of Preventive Cardiology·Roberto FerrariUNKNOWN CLARIFY Registry Investigators
Jun 20, 2014·European Journal of Preventive Cardiology·Rajeev GuptaSalim Yusuf
Jun 1, 2017·Clinical Cardiology·Emmanuel SorbetsUNKNOWN CLARIFY Investigators
Mar 7, 2018·Advances in Therapy·Maria GlezerYuri Karpov
Mar 21, 2018·Current Medical Research and Opinion·Yundai ChenTianlun Yang
Dec 10, 2014·Medicina·Inga BalodeUNKNOWN CLARIFY Registry Investigators
Oct 2, 2015·Medicina·Andrejs ErglisUNKNOWN CLARIFY registry investigators
Sep 16, 2017·Wiener klinische Wochenschrift·Irene M LangPhilippe Gabriel Steg
Nov 3, 2017·Pharmacogenomics·Xiaofeng GaoHui Chen
Aug 3, 2017·Current Medical Research and Opinion·Yundai ChenTae-Hoon Kim
Aug 24, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Taku InoueYusuke Ohya
Feb 23, 2019·Heart·Sumeet GandhiJacob Allan Udell
Feb 27, 2016·The Annals of Pharmacotherapy·Erin R WeedaC Michael White
Aug 28, 2017·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Javaid IqbalBernard J Gersh
Nov 9, 2017·Cardiology and Therapy·Dimitar DivchevUNKNOWN study investigators
May 21, 2020·Cardiology and Therapy·Maria G GlezerUNKNOWN ODA investigators
Nov 27, 2014·Postgraduate Medical Journal·Omar JavedMagdi El-Omar
Jul 20, 2016·Advances in Therapy·Stefan PeringsUNKNOWN RESPONSIfVE study investigators
Apr 20, 2017·Current Medical Research and Opinion·Mikhail Ya RudaYunona V Khomitskaya
Mar 30, 2020·Advances in Therapy·Jolita BadarienėVilma Dženkevičiūtė
Feb 18, 2015·Advances in Therapy·Karl WerdanUrsula Müller-Werdan
Sep 29, 2019·European Journal of Preventive Cardiology·Simone BiscagliaUNKNOWN CLARIFY investigators
Nov 29, 2020·Cardiology and Therapy·Maria Glezer, UNKNOWN CHOICE-2 study investigators
Dec 5, 2020·Clinical Cardiology·Arthur DarmonPhilippe Gabriel Steg
Jul 18, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Amy A KirkhamCarla M Prado
May 16, 2021·Advances in Therapy·Sergey A BoytsovUNKNOWN STYLE study investigators
May 21, 2021·The American Journal of Cardiology·Arthur DarmonUNKNOWN CLARIFY Investigators
Sep 1, 2021·The American Journal of Cardiology·Amanuel Godana AreroDanesh Soltani
Sep 14, 2021·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Sofia BianchiSalvatore Riccobono
Aug 22, 2017·Indian Heart Journal·Upendra KauLRam Kirti Saran