Heart rate and use of beta-blockers in stable outpatients with coronary artery disease.

PloS One
Ph Gabriel StegCLARIFY Investigators

Abstract

Heart rate (HR) is an emerging risk factor in coronary artery disease (CAD). However, there is little contemporary data regarding HR and the use of HR-lowering medications, particularly beta-blockers, among patients with stable CAD in routine clinical practice. The goal of the present analysis was to describe HR in such patients, overall and in relation to beta-blocker use, and to describe the determinants of HR. CLARIFY is an international, prospective, observational, longitudinal registry of outpatients with stable CAD, defined as prior myocardial infarction or revascularization procedure, evidence of coronary stenosis of >50%, or chest pain associated with proven myocardial ischemia. A total of 33,438 patients from 45 countries in Europe, the Americas, Africa, Middle East, and Asia/Pacific were enrolled between November 2009 and July 2010. Most of the 33,177 patients included in this analysis were men (77.5%). Mean (SD) age was 64.2 (10.5) years, HR by pulse was 68.3 (10.6) bpm, and by electrocardiogram was 67.2 (11.4) bpm. Overall, 44.0% had HR ≥ 70 bpm. Beta-blockers were used in 75.1% of patients and another 14.4% had intolerance or contraindications to beta-blocker therapy. Among 24,910 patients on beta-blockers, 41.1% h...Continue Reading

References

Mar 11, 1990·The American Journal of Cardiology·A HjalmarsonJ Ross
Jun 1, 1999·JAMA : the Journal of the American Medical Association·P A HeidenreichM A Hlatky
Jun 25, 1999·BMJ : British Medical Journal·N FreemantleJ Harrison
Oct 11, 2005·European Heart Journal·Jean-Claude TardifUNKNOWN INITIATIVE Investigators
Jan 11, 2007·Archives of Internal Medicine·Philippe Gabriel StegUNKNOWN GRACE Investigators
Jan 19, 2007·The New England Journal of Medicine·Gerard F Anderson, Edward Chu
Aug 28, 2007·Journal of the American College of Cardiology·Kim FoxUNKNOWN Heart Rate Working Group
Feb 6, 2009·BMJ : British Medical Journal·Judith HsiaUNKNOWN Women's Health Initiative Research Group
Apr 1, 2010·Postgraduate Medical Journal·Caroline A DalyUNKNOWN Euro Heart Survey Investigators
Aug 19, 2010·Circulation. Cardiovascular Quality and Outcomes·Alan J BagnallUNKNOWN Canadian Acute Coronary Syndromes Registry II Investigators

❮ Previous
Next ❯

Citations

Oct 30, 2012·Current Treatment Options in Cardiovascular Medicine·Kelly Axsom, Sripal Bangalore
Nov 19, 2013·The Canadian Journal of Cardiology·Sumeet GandhiUNKNOWN Prospective Observational Longitudinal Registry of Patients With Stable Coronary Artery Disease CLARIFY Registry Investigato
Aug 26, 2014·European Journal of Preventive Cardiology·Roberto FerrariUNKNOWN CLARIFY Registry Investigators
Dec 10, 2014·Medicina·Inga BalodeUNKNOWN CLARIFY Registry Investigators
Aug 24, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Taku InoueYusuke Ohya
Feb 23, 2019·Heart·Sumeet GandhiJacob Allan Udell
Feb 27, 2016·The Annals of Pharmacotherapy·Erin R WeedaC Michael White
Aug 28, 2017·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Javaid IqbalBernard J Gersh
May 21, 2020·Cardiology and Therapy·Maria G GlezerUNKNOWN ODA investigators
Sep 29, 2019·European Journal of Preventive Cardiology·Simone BiscagliaUNKNOWN CLARIFY investigators
Nov 29, 2020·Cardiology and Therapy·Maria Glezer, UNKNOWN CHOICE-2 study investigators
Jul 18, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Amy A KirkhamCarla M Prado
Sep 14, 2021·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Sofia BianchiSalvatore Riccobono

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary artery bypass

Clinical Trials Mentioned

ISRCTN43070564
ISRCTN61576291

Software Mentioned

CLARIFY

Related Concepts

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.