Heart rate changes during positive pressure ventilation after asphyxia-induced bradycardia in a porcine model of neonatal resuscitation

Archives of Disease in Childhood. Fetal and Neonatal Edition
Maria Liza EspinozaGeorg M Schmölzer

Abstract

The Neonatal Resuscitation Program (NRP) states that if adequate positive pressure ventilation (PPV) was given for a low heart rate (HR), the infant's HR should increase within the first 15 s of PPV. To assess changes in HR in piglets with asphyxia-induced bradycardia. Term newborn piglets (n=30) were anaesthetised, intubated, instrumented and exposed to 50 min normocapnic hypoxia followed by asphyxia. Asphyxia was achieved by clamping the tube until severe bradycardia (defined as HR at <25% of baseline). This was followed by 30 s adequate PPV and chest compression thereafter. Changes in HR during the 30 s of PPV were assessed and divided into four epochs (0-10 s, 5-15 s, 10-20 s and 20-30 s, respectively). Increase in HR >100/min was observed in 6/30 (20%) after 30 s of PPV. Within the epochs 0-10 s, 5-15 s or 10-20 s no piglet had an increase in HR >100/min. Additional 10/30 (33%) had a >10% increase in HR. In contrast to NRP recommendation, adequate PPV does not increase HR within 15 s after ventilation in piglets with asphyxia-induced bradycardia.

Citations

Jun 26, 2020·Frontiers in Pediatrics·Xueyu ChenChuanzhong Yang
Feb 28, 2020·Healthcare·Peter A Johnson, Georg M Schmölzer
Sep 9, 2019·Seminars in Perinatology·Georg M SchmölzerOmar C O F Kamlin

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