Heart Rate-corrected QT Interval Duration in Rheumatoid Arthritis and Its Reduction with Treatment with the Interleukin 6 Inhibitor Tocilizumab

The Journal of Rheumatology
Hitomi KobayashiJon T Giles

Abstract

Individuals with rheumatoid arthritis (RA) are at a heightened risk of sudden cardiac death, an outcome increased in those with prolongation of the corrected electrocardiographic QT interval (QTc). We compared QTc between patients with RA and demographically matched controls and studied the change in QTc after treatment with the interleukin 6 inhibitor tocilizumab (TCZ). Standard 12-lead electrocardiograms were obtained and QTc was measured in patients with RA at baseline and after 24 weeks of TCZ treatment, then compared with non-RA controls who were frequency-matched on age and sex. Indicators of the baseline QTc and predictors of change in QTc were studied using multivariable linear regression. A total of 94 RA and 42 non-RA controls were studied. The average baseline QTc was 10 ms longer in the RA group vs controls (422 vs 412 ms, respectively; p < 0.001) and decreased to an average of 406 ms with treatment (p < 0.001). Baseline QTc was significantly and independently higher among those with anticyclic citrullinated peptide antibodies seropositivity, higher swollen joint counts, and higher levels of C-reactive protein (CRP) and matrix metalloproteinase 3. Each log unit decrease in CRP with treatment was associated with an a...Continue Reading

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Citations

May 7, 2020·European Heart Journal. Acute Cardiovascular Care·Niyada NaksukThoetchai Bee Peeraphatdit
Sep 28, 2020·Journal of Clinical Pharmacy and Therapeutics·Rashmi R Shah
Aug 26, 2020·Journal of Clinical Medicine·Núria FarréBeatriz Vaquerizo
Sep 21, 2019·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Katherine C WuWendy S Post
Sep 19, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Kiran Haresh Kumar PatelFu Siong Ng
Sep 12, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Georgios MavraganisMeletios-Athanasios Dimopoulos
Aug 21, 2020·Postgraduate Medical Journal·Carlotta SciaccalugaSerafina Valente

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