Heart rate-corrected QT interval helps predict mortality after intentional organophosphate poisoning.

PloS One
Shou-Hsuan LiuTzung-Hai Yen

Abstract

In this study, we investigated the outcomes for patients with intentional organophosphate poisoning. Previous reports indicate that in contrast to normal heart rate-corrected QT intervals (QTc), QTc prolongation might be indicative of a poor prognosis for patients exposed to organophosphates. We analyzed the records of 118 patients who were referred to Chang Gung Memorial Hospital for management of organophosphate poisoning between 2000 and 2011. Patients were grouped according to their initial QTc interval, i.e., normal (<0.44 s) or prolonged (>0.44 s). Demographic, clinical, laboratory, and mortality data were obtained for analysis. The incidence of hypotension in patients with prolonged QTc intervals was higher than that in the patients with normal QTc intervals (P = 0.019). By the end of the study, 18 of 118 (15.2%) patients had died, including 3 of 75 (4.0%) patients with normal QTc intervals and 15 of 43 (34.9%) patients with prolonged QTc intervals. Using multivariate-Cox-regression analysis, we found that hypotension (OR = 10.930, 95% CI = 2.961-40.345, P = 0.000), respiratory failure (OR = 4.867, 95% CI = 1.062-22.301, P = 0.042), coma (OR = 3.482, 95% CI = 1.184-10.238, P = 0.023), and QTc prolongation (OR = 7.459, 95...Continue Reading

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Citations

Apr 29, 2014·The American Journal of Emergency Medicine·Changwoo KangKyung-Woo Lee
Mar 25, 2014·Environmental Science and Pollution Research International·Neha AtaleVibha Rani
Oct 11, 2015·Talanta·Tzung-Hai YenChao-Min Cheng
Oct 17, 2013·SpringerPlus·Hsin-Ying YuTzung-Hai Yen
Apr 28, 2020·Human & Experimental Toxicology·H-F LiuT-H Yen
Aug 9, 2020·Neuropsychiatric Disease and Treatment·Wei-Chen HuangShwu-Hua Lee
Jan 29, 2021·World Journal of Emergency Medicine·Ning DongJi-Hong Xing
Apr 20, 2020·Biochemical Pharmacology·Kayla D BouknightPatricia M Legler
Apr 2, 2021·PloS One·Chih-Chuan LinGwo-Jyh Chang

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Methods Mentioned

BETA
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Software Mentioned

SPSS

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