Heart rate dynamics during accentuated sympathovagal interaction

The American Journal of Physiology
Mikko P TulppoH V Huikuri

Abstract

Concomitant sympathetic and vagal activation can occur in various physiological conditions, but there is limited information on heart rate (HR) behavior during the accentuated sympathovagal antagonism. Beat-to-beat HR and blood pressure were recorded during intravenous infusion of incremental doses of norepinephrine in 18 healthy male volunteers (mean age 23 +/- 5 yr). HR and blood pressure spectra and two-dimensional Poincaré plots were generated from the baseline recordings and from the recordings at different doses of norepinephrine. The mean blood pressure increased (from 90 +/- 7 to 120 +/- 9 mmHg, P < 0.001), HR decreased (from 60 +/- 9 to 48 +/- 7 beats/min, P < 0.001), and the high-frequency spectral component of HR variability increased (P < 0.001) during the norepinephrine infusion as evidence of accentuated sympathovagal interaction. Abrupt aperiodic changes in sinus intervals that were not related to respiratory cycles or changes in blood pressure occurred in 14 of 18 subjects during the norepinephrine infusions. These fluctuations in sinus intervals resulted in a complex or parabola-shaped structure of the Poincaré plots of successive R-R intervals and a widening of the high-frequency spectral peak. In four subject...Continue Reading

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Citations

Sep 25, 2010·Clinical Cardiology·Steven E HaineChris J Vrints
Feb 18, 2015·Computational and Mathematical Methods in Medicine·Berik KoichubekovXenia Mkhitaryan
Jul 23, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Ana Paula Cardoso-de-Mello-E-Mello-RibeiroÁngel Oliva-Pascual-Vaca
Sep 22, 2005·Journal of Cardiovascular Electrophysiology·Phyllis K SteinJohn Gottdiener
Oct 9, 2009·Physiological Measurement·C K KarmakarM Palaniswami
Feb 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·M P TulppoH V Huikuri
Feb 3, 2007·The Journal of Physiological Sciences : JPS·Przemysław GuzikHenryk Wysocki
Feb 27, 2007·Physiological Measurement·J Piskorski, P Guzik
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·D P HolschneiderJ C Shih
Jul 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Antti M KiviniemiMikko P Tulppo
Dec 17, 2008·American Journal of Physiology. Heart and Circulatory Physiology·M BuchheitP B Laursen
Apr 9, 2019·Proceedings·Mary LeeGreg Olsovsky
Apr 12, 2019·Frontiers in Physiology·Mikko P TulppoHeikki V Huikuri
Mar 26, 2003·Journal of Applied Physiology·Mikko P TulppoHeikki V Huikuri
Oct 9, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Mikko P TulppoJ Kevin Shoemaker
May 23, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A PortaP Van Leeuwen
Aug 8, 2014·Frontiers in Psychology·Daniel S Quintana, James A J Heathers
Oct 22, 2020·Rehabilitation Research and Practice·Perciliany Martins de SouzaGabriela Guerra Leal Souza
Nov 18, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Michael J MacartneyGlen P Kenny

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