Heart rate dynamics in doxorubicin-induced cardiomyopathy

Physiological Measurement
T Lončar-TurukaloN Japunžić-Žigon

Abstract

The clinical use of doxorubicin, an effective chemotherapeutic is hampered by the development of irreversible cardiotoxicity. Here we test time-frequency analysis of heart rate (HR) variability (HRV) for early detection of doxorubicin-induced cardiotoxicity. Experiments were conducted in adult male Wistar rats treated for 15 days with doxorubicin (DOXO, total dose 15 mg kg(-1), i.p.) or saline (CONT). DOXO rats exhibited cardiotoxicity confirmed by histological examination without developing heart failure as estimated by echocardiography. However, HR variability increase reflected subtle microscopic changes of cardiac toxicity in DOXO rats. The results recommend time-frequency analysis of HRV for early detection of doxorubicin-induced cardiomyopathy.

References

Jun 1, 1990·Journal of the Autonomic Nervous System·N JapundzicJ L Elghozi
Mar 1, 1991·The American Journal of Physiology·J TongP K Singal
Jun 2, 1998·Clinical and Experimental Hypertension : CHE·N Japundzic-Zigon
May 2, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·V B Pai, M C Nahata
Dec 13, 2000·European Journal of Heart Failure·K TeraokaA Yamashina
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Michael BrennanPeter Kamen
Jan 28, 2005·Journal of Cardiovascular Electrophysiology·Phyllis K SteinUNKNOWN Cast Investigators
Sep 29, 2006·Basic Research in Cardiology·Adam B SteinBuddhadeb Dawn
Feb 27, 2007·Physiological Measurement·J Piskorski, P Guzik
Dec 18, 2009·Cardiology·Kanu ChatterjeeJoel S Karliner
Oct 7, 2010·IEEE Transactions on Bio-medical Engineering·Tatjana Loncar TurukaloNina Japundzic Zigon
Mar 5, 2011·The American Journal of Cardiology·Heloisa SawayaMarielle Scherrer-Crosbie
Apr 3, 2012·Journal of Molecular and Cellular Cardiology·Yanti OctaviaAn L Moens
Nov 20, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G CuriglianoUNKNOWN ESMO Guidelines Working Group
Jan 22, 2013·Autonomic Neuroscience : Basic & Clinical·Clive N MayRohit Ramchandra
Jun 7, 2013·PloS One·Nolwenn MerletChantal Gauthier
Oct 19, 2013·Experimental and Therapeutic Medicine·Yongqiang FengHongjie Duan
Nov 13, 2013·Progress in Cardiovascular Diseases·Heikki V Huikuri, Phyllis K Stein
May 6, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Peter R PellegrinoIrving H Zucker
Jul 2, 2014·Pharmacology, Biochemistry, and Behavior·S AziriovaF Simko

❮ Previous
Next ❯

Citations

Jan 2, 2016·Chemico-biological Interactions·Rong WuJian-Ping Gao
Nov 7, 2015·Journal of Cardiovascular Pharmacology·Nasser RazmaraiiYadollah Azarmi
May 8, 2020·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Jie PanTing Liu
Oct 21, 2017·European Journal of Preventive Cardiology·Nina Japundžić-ŽigonDavid Murphy
Nov 10, 2020·Physiological Measurement·Dorota SztechmanAgnieszka Cudnoch-Jędrzejewska
May 21, 2021·Toxicology and Applied Pharmacology·Vladislav PajovićNina Japundžić-Žigon
Jun 11, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·You-Ping WuZhen-Qiang You

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

Related Papers

The New England Journal of Medicine
J H Doroshow
The New England Journal of Medicine
L Paz-AresC Twelves
The New England Journal of Medicine
J H Silber, G Barber
Postgraduate Medical Journal
L Samuel
American Journal of Physiology. Heart and Circulatory Physiology
Xiaoming YiRalph V Shohet
© 2021 Meta ULC. All rights reserved