PMID: 11323088Apr 27, 2001Paper

Heart rate elevation and diabetic retinopathy in patients with type 2 diabetes mellitus and normoalbuminuria

Diabetes Research and Clinical Practice
E ImanoM Hori

Abstract

To investigate the role of heart rate (HR) and blood pressure (BP) for diabetic retinopathy, 24-h ambulatory HR and BP were monitored for 162 in patients with type 2 diabetes and normoalbuminuria. The fundus was assessed as no retinopathy, simple diabetic retinopathy (SDR) and proliferative retinopathy (PDR). Comparing the highest with the lowest quartile of diabetic duration, the relative risk for retinopathy was 9.3 and for nocturnal HR, it was 3.6. Comparison among three retinopathy groups (no retinopathy, group 1, n=122; SDR, group 2, n=24; Pre-PDR or PDR, group 3, n=16) showed that 24-h and nocturnal HR were significantly higher in group 3 (80+/-9 and 71+/-9 beats per min) than in group 2 (73+/-8 and 64+/-8) and group 1 (72+/-7 and 60+/-7). In multiple logistic analysis, the odds ratio of diabetic duration and nocturnal HR to the existence of retinopathy was 1.17 (95% CI, 1.10-1.25, P=0.00001) and 1.11 (95% CI, 1.05-1.17, P=0.0002). We concluded that diabetic retinopathy is related to diabetic duration and high heart rate in type 2 diabetes mellitus with normoalbuminuria. Heart rate elevation may be a predictor of advanced retinopathy.

References

Oct 1, 1988·Ophthalmology·S E MossB E Klein
Aug 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·R E GilbertG Jerums
Jul 19, 1997·Lancet·R Klein, B E Klein

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Citations

Dec 18, 2001·Diabetes/metabolism Research and Reviews·B NazlielB Koçer
Feb 5, 2004·The Journal of Pediatrics·Ze'ev Korzets, Avishalom Pomeranz
Feb 6, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Rie KomaiUNKNOWN J-HOME Study Group
Feb 18, 2016·Cardiovascular Diabetology·Timothy J BradleyDavid Z I Cherney
Jul 31, 2013·The Journal of Clinical Hypertension·Tomislav BulumLea Duvnjak
Mar 1, 2015·Acta Psychologica·David MoreauAndrew R A Conway
Jan 17, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C K KramerJ L Gross
Sep 1, 2017·The British Journal of Ophthalmology·Guihua ZhangMingzhi Zhang
Jan 15, 2013·Journal of the American Heart Association·Graham S HillisJohn Chalmers
Mar 28, 2019·Journal of Ophthalmology·Kohei IchinohasamaToru Nakazawa

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