Heart rate per se impacts cardiac function in patients with systolic heart failure and pacing: a pilot study

European Journal of Heart Failure
Damien LogeartGuillaume Jondeau

Abstract

This study was designed to compare the specific effects of two heart rates (HR), 55 and 75 b.p.m., in patients with heart failure (HF). Patients with chronic HF, left ventricular ejection fraction (LVEF) </= 35%, and a pacemaker with >90% of paced QRS, were included in a randomized cross-over trial of two 3-month periods where pacing rate was set at either 55 or 75 b.p.m. At the end of each period, patients were examined and radionuclide ventriculography, echocardiography, and blood sampling were performed for centralized and blinded analysis. Two patients did not complete the study because of early worsening while paced at 75 b.p.m. Twelve patients completed the study. Compared with 75 b.p.m., pacing at 55 b.p.m. was associated with a higher LVEF [+4.7% (2.6-6.7), P < 0.001], lower B-type natriuretic peptide levels [-91 pg/mL (-148 to -33), P < 0.01], lower systolic pulmonary artery pressure (41 +/- 10 vs. 47 +/- 10 mmHg, P = 0.02) and lower NYHA (New York Heart Association) class (2.2 +/- 0.6 vs. 2.6 +/- 0.5, P = 0.03). The baseline pacing rate prior to inclusion had no effect on results. HR per se may impact cardiac function and low HR might be beneficial in patients with systolic HF compared with intermediate HR.

References

Mar 27, 1999·Heart·T LapercheR Gourgon
Sep 19, 2000·Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology·R Latini, S Masson
Oct 26, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Patrice ColinAlain Berdeaux
Mar 9, 2005·The New England Journal of Medicine·John G F ClelandUNKNOWN Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators
Oct 13, 2005·European Heart Journal·Stuart J PocockChristopher B Granger
Feb 10, 2006·European Journal of Heart Failure·Cristina OpasichUNKNOWN BRING-UP 2 Investigators
Apr 24, 2007·Journal of the American College of Cardiology·Patrick JourdainYves Juillière
May 23, 2007·Journal of Cardiac Failure·Krishnamurti RaoStephen S Gottlieb
Jun 2, 2007·American Heart Journal·Michael B FowlerUNKNOWN COHERE Participant Physicians
Aug 28, 2007·Journal of the American College of Cardiology·Kim FoxUNKNOWN Heart Rate Working Group
Sep 29, 2007·The Journal of Pharmacology and Experimental Therapeutics·Vlad CiobotaruDamien Logeart

❮ Previous
Next ❯

Citations

May 22, 2010·The Journal of Physiological Sciences : JPS·Nidas A UndrovinasAlbertas Undrovinas
Jan 2, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Marcus StåhlbergFrieder Braunschweig
Aug 26, 2009·Journal of Internal Medicine·J Kjekshus
Jul 10, 2010·Journal of Renal Care·Donald S SilverbergDoron Schwartz
Apr 30, 2015·European Heart Journal·Roberto Ferrari, Kim M Fox
Dec 3, 2014·The American Journal of Medicine·Michael BöhmJeffrey S Borer
May 27, 2016·Nature Reviews. Cardiology·Roberto Ferrari, Kim Fox
Mar 25, 2017·Scandinavian Cardiovascular Journal : SCJ·Jan NaarMarcus Ståhlberg
Jan 19, 2020·The International Journal of Cardiovascular Imaging·Jingdu TianLan Huang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.