Heart rate variability and cardiac repolarization after exposure to zinc oxide nanoparticles in healthy adults

Journal of Occupational Medicine and Toxicology
Assem AweimerRolf Merget

Abstract

Exposure to airborne zinc oxide (ZnO) particles occurs in many industrial processes, especially in galvanizing and welding. Systemic inflammation after experimental inhalation of ZnO particles has been demonstrated previously, but little is known about the impact on the cardiovascular system, particularly on the autonomic cardiac system and the risk of arrhythmias. In this study we investigated the short-term effects of ZnO nanoparticles on heart rate variability (HRV) and repolarization in healthy adults in a concentration-dependent manner at rest and during exercise in a controlled experimental set-up. Sixteen healthy subjects were exposed to filtered air and ZnO particles (0.5, 1.0 and 2.0 mg/m3) for 4 h, including 2 h of cycling at low workloads. Parameters were assessed before, during, immediately after, and about 24 h after each exposure. For each subject, a total number of 46 10-min-sections from electrocardiographic records were analyzed. Various parameters of HRV and QT interval were measured. Overall, no statistically significant effects of controlled ZnO inhalation on HRV parameters and QT interval were observed. Additionally, a concentration-response was absent. Inhalation of ZnO nanoparticles up to 2.0 mg/m3 for 4 ...Continue Reading

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Methods Mentioned

BETA
scanning electron microscopy

Software Mentioned

Scribe
of Mortara
SuperECG
Mortara
KubiosHRV

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