Heart rate variability and serum level of insulin-like growth factor-1 are correlated with symptoms of emotional disorders in patients suffering a mild traumatic brain injury

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Chih-Wei SungJia-Yi Wang

Abstract

Patients who have experienced a mild traumatic brain injury (mTBI) are susceptible to symptoms of anxiety or depression. To explore the potential biomarkers for emotional disorders in mTBI patients, we analyzed the frequency domain of heart rate variability (HRV) and serum concentrations of four neurohormones. We assessed mTBI patients on their first visit and follow-up. Symptoms were evaluated by the Beck Anxiety Inventory and the Beck Depression Inventory, respectively. Serum levels of adrenocorticotropic hormone (ACTH), melatonin, cortisol, and insulin-like growth factor (IGF)-1 and HRV follow-ups were measured and compared. mTBI patients were more vulnerable to symptoms of anxiety or depression than healthy controls. Reduced HRV was noted in mTBI patients compared to healthy controls. The mTBI patients demonstrated higher serum levels of ACTH, lower IGF-1 compared to healthy controls. In correlation analysis, only IGF-1 was positively correlated with HRV in mTBI patients. Both HRV and IGF-1 were correlated with symptom of depression while only HRV was correlated with symptom of anxiety in mTBI patients. We infer that HRV may be more significantly correlated with emotional disorders than is IGF-1 in mTBI patients. The study ...Continue Reading

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Citations

Mar 21, 2018·Neurorehabilitation and Neural Repair·Olivia A GaleaShaun P O'Leary
Jan 8, 2020·Journal of Athletic Training·Blair D JohnsonJohn J Leddy
Feb 6, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John L DobsonThomas Buckley
Apr 29, 2019·Journal of Neurology·Harm Jan van der HornJoukje van der Naalt

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