Heart rate variability and the risk of Parkinson disease: The Atherosclerosis Risk in Communities study

Annals of Neurology
Alvaro AlonsoHonglei Chen

Abstract

Autonomic dysfunction frequently occurs in the context of Parkinson disease (PD) and may precede onset of motor symptoms. Limited data exist on the prospective association of heart rate variability (HRV), a marker of autonomic function, with PD risk. We included 12,162 participants of the Atherosclerosis Risk in Communities study, a community-based cohort, without a diagnosis of PD at baseline (1987-1989) and with available HRV data (mean age = 54 years, 57% women). A 2-minute electrocardiogram was used to measure HRV. Incident PD was identified through 2008 from multiple sources, and adjudicated. Multivariable Cox models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of PD by quartiles of HRV measurements. During a mean follow-up of 18 years, we identified 78 incident PD cases. Lower values of the root mean square of successive differences in normal-to-normal R-R intervals (rMSSD) and standard deviation of normal-to-normal R-R intervals (SDNN), markers of parasympathetic activity and total variability, respectively, were associated with higher PD risk during follow-up. In multivariate models, the HR (95% CI) of PD in the bottom quartiles of rMSSD and SDNN compared to the top quartiles were 2.1 (1....Continue Reading

References

Jul 1, 1985·American Journal of Epidemiology·W C WillettFrank E Speizer
Apr 1, 1996·Computers and Biomedical Research, an International Journal·D LiaoGerardo Heiss
Aug 1, 1996·Cardiovascular Research·F LombardiS Cerutti
Feb 22, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·T HaapaniemiV Myllylä
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Mar 23, 2005·Brain Pathology·Takeshi AminoHidehiro Mizusawa
Mar 3, 2009·Neurology·Eduardo TolosaYaroslau Compta
Apr 21, 2009·Lancet Neurology·K Ray Chaudhuri, Anthony H V Schapira
Feb 2, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Nicolas SauvageotNico J Diederich
Oct 20, 2011·Acta Neurologica Scandinavica·E TrachaniE Chroni
Nov 19, 2011·Neurobiology of Disease·Samay Jain, David S Goldstein
Jun 16, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Samay JainWill T Longstreth

Citations

Sep 30, 2015·Expert Review of Neurotherapeutics·Kai LiTjalf Ziemssen
Nov 5, 2015·Journal of Neurology·Inga Liepelt-ScarfoneDaniela Berg
Sep 25, 2015·Neurology·Horacio Kaufmann, Giris Jacob
Apr 20, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Srishti ShresthaHonglei Chen
Aug 20, 2016·Journal of the Neurological Sciences·Jung Han YoonJi Man Hong
Oct 7, 2016·European Journal of Internal Medicine·Shih-Yi LinChun-Hung Tseng
Feb 3, 2017·Epilepsy & Behavior : E&B·Alan W C Yuen, Josemir W Sander
Apr 5, 2016·PloS One·Shaza M MusaMohamed F Lutfi
Jan 11, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Naomi P VisanjiConnie Marras
Oct 28, 2016·Nature Reviews. Neurology·Ronald B Postuma, Daniela Berg
Aug 15, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Sebastian HeinzelMDS Task Force on the Definition of Parkinson's Disease
Jun 22, 2019·Scientific Reports·Laís D RodriguesFulvio Alexandre Scorza
Jul 12, 2017·Journal of Molecular Neuroscience : MN·Fatemeh Nouri Emamzadeh
Sep 19, 2017·Journal of Parkinson's Disease·Karoline KnudsenPer Borghammer
Mar 4, 2020·Pharmacological Reports : PR·Mariana Bocca NejmCarla Alessandra Scorza
Jul 25, 2018·Journal of Parkinson's Disease·Ahmed Al-QassabiRonald B Postuma
Feb 26, 2019·Frontiers in Neurology·Chien-Tai HongLi-Nien Chien
Nov 7, 2019·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Lucy Norcliffe-Kaufmann
Jan 9, 2020·The New England Journal of Medicine·Horacio KaufmannJose-Alberto Palma
May 17, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Andrea PilottoDaniela Berg
Dec 22, 2019·Journal of Clinical Medicine·Tatjana ReyndersMarie B D'hooghe
May 16, 2019·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·Alyne Montero FerroAnna Carolyna Gianlorenço
Jul 11, 2020·Scientific Reports·Oguz AkbilgicSamuel M Goldman
Jan 27, 2021·International Journal of Molecular Sciences·Vinita G Chittoor-VinodBirgitt Schüle
Mar 7, 2021·European Journal of Epidemiology·Elisa LonginettiFang Fang
Apr 1, 2021·International Journal of General Medicine·Ling-Ling ZhongHua Cao
Apr 5, 2021·Frontiers in Physiology·Jeann L Sabino-CarvalhoLauro C Vianna
Apr 21, 2021·Nature Reviews. Neurology·Daniela BergRonald B Postuma
Apr 29, 2021·JCO Clinical Cancer Informatics·Fatma GüntürkünDaniel A Mulrooney

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

Related Papers

Autonomic Neuroscience : Basic & Clinical
Christopher H GibbonsNINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators
Clinical, Cosmetic and Investigational Dermatology
Astrid-Helene RavnAlexander Egeberg
Stroke; a Journal of Cerebral Circulation
Amber L Fyfe-JohnsonRichard F MacLehose
© 2021 Meta ULC. All rights reserved