Heart rate variability and vagal tone in schizophrenia: A review

Journal of Psychiatric Research
Julian M MontaquilaJeffrey S Bedwell

Abstract

Recent heart rate variability (HRV) research has identified diminished levels of parasympathetic activity among schizophrenia patients. Over two dozen empirically-based studies have been published on this topic; primarily over the last decade. However, no theoretical review appears to have been published on this work. Further, only one empirical study has evaluated HRV research findings in the context of documented hypothalamic-pituitary-adrenal axis hyperactivity in schizophrenia. HRV research indicates that no abnormalities exist in the initial sympathetic stress response of schizophrenia patients. However, evidence has consistently demonstrated that patients exhibit a diminished capacity to recover from a stress response as a result of deficits in parasympathetic activity. Moreover, this diminished parasympathetic nervous system (PNS) response, also known as decreased vagal tone, has been found to relate to increased symptom severity. Although these findings may cause speculation that the observed vagal tone disruption merely results from anxiety produced by the presence of positive symptomology, additional studies have identified similar parasympathetic dysfunction among nonpsychotic relatives of individuals with schizophre...Continue Reading

References

Jan 1, 1979·Schizophrenia Bulletin·H E Spohn, T Patterson
Nov 21, 1990·JAMA : the Journal of the American Medical Association·D A RegierF K Goodwin
Nov 1, 1983·Journal of Affective Disorders·A CoppenK Wood
Aug 1, 1981·The Journal of Nervous and Mental Disease·J Zubin, S Steinhauer
Oct 24, 1997·Archives of General Psychiatry·T P ZahnJ L Rapoport
Feb 13, 1999·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·M ToichiK Miyoshi
Oct 18, 2000·European Journal of Pharmacology·C C Gispen-de Wied
Feb 13, 2001·Journal of Affective Disorders·J F Thayer, R D Lane
Aug 29, 2001·Development and Psychopathology·E F WalkerF Reynolds
Aug 31, 2001·Biological Psychiatry·R A ChambersD W Self
May 1, 1964·British Journal of Psychology·P H VENABLES
Dec 31, 2003·Psychophysiology·Minna Valkonen-KorhonenJohannes Lehtonen
Jan 31, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jong-Hoon KimYong Sik Kim
Mar 25, 2005·Psychophysiology·Gary G BerntsonYun-Ju Chen
Jul 5, 2005·Journal of Psychiatric Research·Roelie J HempelMichiel W Hengeveld
Jul 5, 2005·Journal of Psychiatric Research·K J BärH Sauer
Apr 15, 2006·CNS & Neurological Disorders Drug Targets·M MarinelliF J White
Oct 13, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Silke BoettgerKarl-Jürgen Bär
Mar 14, 2007·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Roelie J HempelMichiel W Hengeveld
Jul 17, 2007·Schizophrenia Research·Karl-Jürgen BärVikram K Yeragani
Jul 25, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Karl-Jürgen BärAndreas Voss
Oct 9, 2007·Psychiatry Research·Karl-Jürgen BärMarcus-Willi Agelink
Feb 20, 2008·Psychophysiology·Gary G BerntsonJohn T Cacioppo
Mar 29, 2008·Annual Review of Clinical Psychology·Elaine WalkerKevin Tessner
Aug 30, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Karl-Jürgen BärAndreas Voss
May 12, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jae Seung ChangYong Sik Kim
Jun 6, 2009·Psychiatry and Clinical Neurosciences·Mami FujibayashiToshio Moritani
Aug 25, 2009·Journal of Psychiatric Research·Brook L HenryWilliam Perry
Apr 29, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jae Seung ChangYong Min Ahn
May 12, 2010·Journal of Abnormal Psychology·Elaine F WalkerMichael T Compton
Sep 17, 2011·European Psychiatry : the Journal of the Association of European Psychiatrists·A BirkhoferG Schmidt
Nov 30, 2011·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Oscar Ignacio JáureguiSalvador M Guinjoan
Feb 9, 2012·Journal of Korean Academy of Nursing·Kyunghee LeeChang Gi Park
Feb 21, 2013·Journal of Clinical Psychopharmacology·Wei-Lieh HuangCheryl C H Yang

❮ Previous
Next ❯

Citations

Mar 9, 2017·BMC Psychiatry·Masatoshi MiyauchiYoshio Hirayasu
Jun 28, 2017·Physiological Measurement·Erik ReinertsenGari D Clifford
May 27, 2020·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Wei-Chia HuangWei-Lieh Huang
Jul 21, 2020·Psychological Medicine·David BaumeisterEmmanuelle Peters
Sep 18, 2018·Physiological Measurement·Erik ReinertsenGari D Clifford
May 28, 2019·Frontiers in Physiology·Martin H LundqvistJan W Eriksson
Aug 31, 2016·Early Intervention in Psychiatry·Laina McAusland, Jean Addington
Sep 12, 2017·Journal of Integrative Neuroscience·María J LadoXosé A Vila
Nov 27, 2020·Frontiers in Psychiatry·Anna KocsisPeter J Uhlhaas
Sep 19, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Beatrice R BenjaminDaniel S Quintana
Aug 31, 2020·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·A SuppiejE Cainelli
Feb 20, 2021·Journal of Clinical Psychopharmacology·Johan BengtssonRobert Bodén
Apr 28, 2021·NPJ Schizophrenia·Nicolette StogiosSri Mahavir Agarwal
Nov 23, 2020·Schizophrenia Research·Alexander RefischKarl-Jürgen Bär
Jul 28, 2021·Schizophrenia Research·David BaumeisterEmmanuelle Peters

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here