Heart rate variability in individuals with Down syndrome - A systematic review and meta-analysis

Autonomic Neuroscience : Basic & Clinical
Tatiana Dias de CarvalhoCelso Ferreira

Abstract

Down syndrome (DS) results in many changes, including dysfunction in cardiac autonomic modulation. Heart rate variability (HRV) analysis evaluates the autonomic function and it is a predictor of adverse cardiovascular events. To present results of a systematic review and a meta-analysis about heart rate variability in individuals with DS. A systematic review was performed on PubMed, PubMed Central and Web of science databases. We included articles that exhibited all the terms: "Down Syndrome", "heart rate variability", "autonomic nervous system", "autonomic dysfunction" and "cardiac autonomic modulation". We conducted the meta-analysis to compare "DS" to "controls" during rest. Random effects models were used, as were appropriate tests for heterogeneity. From 271 studies, 13 were included in our review. These are conducted with volunteers from a wide age range, of either gender, and not taking medications. Meta-analysis displayed that there were no significant differences between the groups at rest, except the RMSSD, which revealed a significant (Z = -2.80, p = 0.005) main effect (Hedge's g = -0.55, 95% CI [-0.93; -0.16]), indicating difference in individuals with DS compared with controls. There is autonomic dysfunction in ind...Continue Reading

Citations

Jul 10, 2020·The Journal of Clinical Hypertension·Emilia Roy-VallejoDiego Real de Asúa
Jun 21, 2020·International Journal of Environmental Research and Public Health·Rosa María Martínez-EspinosaManuel Reig García-Galbis
Nov 25, 2020·Pediatric Research·Rosemary S C HorneGillian M Nixon
Nov 11, 2019·Neuroscience and Biobehavioral Reviews·Léa Dumortier, Véronique-Aurélie Bricout
Feb 17, 2021·Journal of Intellectual Disability Research : JIDR·L SutherlandL A Hughes-McCormack
Feb 20, 2021·Pediatric Research·Kaitlin R BlackardKaren D Fairchild

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