PMID: 8945061Nov 1, 1996Paper

Heart rate variability in isolated rabbit hearts

Pacing and Clinical Electrophysiology : PACE
B FreyG Steurer

Abstract

The presence of heart rate variability (HRV) in patients with cardiac denervation after heart transplantation raised our interest in HRV of isolated, denervated hearts. Hearts from seven adult white ELCO rabbits were transferred to a perfusion apparatus. All hearts were perfused in the working mode and in the Langendorff mode for 20 minutes each. HRV was analyzed in the frequency domain. A computer simulated test ECG at a constant rate of 2 Hz was used for error estimation of the system. In the isolated, denervated heart, HRV was of random, broadband fluctuations, different from the well-characterized oscillations at specific frequencies in intact animals. Mean NN was 423 +/- 51 ms in the Langendorff mode, 406 +/- 33 ms in the working heart mode, and 500 ms in the test ECG. Total power was 663 +/- 207 ms2, 817 +/- 318 ms2, and 3.7 ms2, respectively. There was no significant difference in any measure of HRV between Langendorff and working heart modes. The data provide evidence for the presence of HRV in isolated, denervated rabbit hearts. Left atrial and ventricular filling, i.e., the working heart mode, did not alter HRV, indicating that left atrial or ventricular stretch did not influence the sinus nodal discharge rate.

Citations

Sep 8, 2000·Bulletin of Experimental Biology and Medicine·I V MukhinaN A Kamaidanov
Nov 10, 2013·PloS One·Ekaterina PosokhovaKirill A Martemyanov
Oct 17, 2003·High Altitude Medicine & Biology·Alexandre MelinPierre Bonnet
Feb 20, 2020·Physical Review. E·Po-Yu ChouPik-Yin Lai
Jul 20, 2021·Frontiers in Physiology·Ido Weiser-BitounYael Yaniv

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