Heart Rate Variability in Porcine Progressive Peritonitis-Induced Sepsis

Frontiers in Physiology
Dagmar JarkovskaMilan Stengl

Abstract

Accumulating evidence suggests that heart rate variability (HRV) alterations could serve as an indicator of sepsis progression and outcome, however, the relationships of HRV and major pathophysiological processes of sepsis remain unclear. Therefore, in this experimental study HRV was investigated in a clinically relevant long-term porcine model of severe sepsis/septic shock. HRV was analyzed by several methods and the parameters were correlated with pathophysiological processes of sepsis. In 16 anesthetized, mechanically ventilated, and instrumented domestic pigs of either gender, sepsis was induced by fecal peritonitis. Experimental subjects were screened up to the refractory shock development or death. ECG was continuously recorded throughout the experiment, afterwards RR intervals were detected and HRV parameters computed automatically using custom made measurement and analysis MATLAB routines. In all septic animals, progressive hyperdynamic septic shock developed. The statistical measures of HRV, geometrical measures of HRV and Poincaré plot analysis revealed a pronounced reduction of HRV that developed quickly upon the onset of sepsis and was maintained throughout the experiment. The frequency domain analysis demonstrated ...Continue Reading

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Citations

Feb 2, 2017·Journal of Intensive Care Medicine·Jason A Ferreira, Brittany D Bissell
May 6, 2017·Journal of Applied Physiology·Farid YaghoubyChristopher G Scully
Jun 28, 2018·Frontiers in Physiology·Dagmar JarkovskaMilan Stengl
Apr 26, 2017·Experimental Biology and Medicine·Dagmar JarkovskaMilan Stengl

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Software Mentioned

Matlab
Origin
STATISTICA Cz
OriginPro

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