Heart rate variability in the human transplanted heart: nonlinear dynamics and QT vs RR-QT alterations during exercise suggest a return of neurocardiac regulation in long-term recovery

Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society
M MeyerJ E Skinner

Abstract

Functional reinnervation of the transplanted human heart by the autonomic nervous system has not been demonstrated. A lack of autonomic control of the transplanted allograft is reflected by an increased resting heart rate, a sluggish heart rate response to dynamical exercise and a reduced heart rate variability. Recent evidence suggests that a measure of deterministic chaos in the heartbeat interval series (point correlation dimension, PD2i) is superior to the conventional power spectrum or other stochastic measures in detecting changes in the mechanism underlying heartbeat generation. The PD2i is based on the presumption that the variability is determined and patterned, whereas the stochastic measures all assume that the variability is around a stationary mean and is noise. The PD2i reconstructs the degrees of freedom (number of independent variables) in the system that generates the time series examined, and does this irrespective of whether the system is stochastic or deterministic and is stationary in time. PD2i was determined for heartbeat intervals (RR, ECG digitized at 1200 Hz; supine posture) of 23 heart transplant recipients (HTR: 9 adults, 14 children; 0.04-7.7 years after transplantation) and 21 healthy control subje...Continue Reading

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Citations

May 22, 1998·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·M MeyerP Cerretelli
May 20, 1999·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·M MeyerJ E Skinner
Oct 9, 1999·Journal of Cardiovascular Electrophysiology·M CostaE Ducla-Soares
Nov 4, 2000·Journal of Cardiovascular Electrophysiology·P KowallikM Meesmann
Sep 22, 2000·Sports Medicine·R W Braith, D G Edwards
Sep 17, 2003·Sports Medicine·André E AubertFrank Beckers
Sep 9, 2009·Archives of Physical Medicine and Rehabilitation·Arzu OnMustafa Ozbaran
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Jun 12, 2018·Family Process·Joana CoutinhoWolfgang Tschacher
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J E SkinnerW C Dalsey

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