Heart rate variability shows different cardiovascular modulation in Parkinson's disease patients with tremor dominant subtype compared to those with akinetic rigid dominant subtype

Journal of Neural Transmission
Paolo SollaFrancesco Marrosu

Abstract

Parkinson's disease (PD) can present with different motor subtypes depending on the predominant symptoms (tremor or rigidity/bradykinesia). Slower disease progression and less cognitive decline are observed in tremor-dominant patients compared to those with akinetic-rigid subtype. Autonomic cardiovascular disorders have been described in parkinsonian patients, although the definite correlations with different subtypes of PD are not clear. In this context, heart rate variability (HRV) analysis represents a non-invasive and established tool in assessing cardiovascular autonomic modulation. We investigate cardiovascular autonomic modulation in PD patients with tremor dominant subtype in comparison to akinetic rigid dominant subtype subjects using HRV analysis. Twenty-eight PD patients (17 with tremor dominant subtype and 11 with akinetic rigid dominant subtype) were enrolled and compared to 17 age and sex-matched healthy controls. HRV was analyzed in time- and frequency-domains. Low-frequency (LF) values were significantly lower in the akinetic rigid dominant subtype than in the tremor dominant group [LF 41.4 ± 13.6 vs 55.5 ± 11.6 (p < 0.007)] indicating that the disease led to a more evident impairment of the baroreflex modulatio...Continue Reading

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Citations

May 6, 2016·Frontiers in Cellular Neuroscience·Esterina PascaleGiuseppe Meco
Aug 20, 2016·Journal of the Neurological Sciences·Jung Han YoonJi Man Hong
Jan 11, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Naomi P VisanjiConnie Marras
Oct 24, 2017·Neurological Research·Jesús Piqueras-FloresAlfonso Jurado-Román
Apr 30, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Alberto J EspayUNKNOWN Movement Disorders Society Task Force on Technology

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