Heart regeneration and repair after myocardial infarction: translational opportunities for novel therapeutics

Nature Reviews. Drug Discovery
Thomas J CahillPaul R Riley


Current therapies for heart failure after myocardial infarction are limited and non-curative. Although regenerative approaches are receiving significant attention, clinical efforts that involve transplantation of presumed stem and progenitor cells have largely failed to deliver. Recent studies of endogenous heart regeneration in model organisms, such as zebrafish and neonatal mice, are yielding mechanistic insights into the roles of cardiomyocyte proliferation, resident stem cell niches, neovascularization, the immune system and the extracellular matrix. These findings have revealed novel pathways that could be therapeutically targeted to stimulate repair following myocardial infarction and have provided lessons to guide future efforts towards heart regeneration through cellular reprogramming or cardiomyocyte transplantation.


Jul 26, 2018·Journal of Tissue Engineering and Regenerative Medicine·Mireille M J P E SthijnsVanessa L S LaPointe
Aug 30, 2018·American Journal of Respiratory Cell and Molecular Biology·Tadanori MammotoAkiko Mammoto
Mar 12, 2018·Journal of Cardiovascular Translational Research·Jing NiZheng Liu
Mar 17, 2018·Scientific Reports·Sini M KinnunenHeikki Ruskoaho
Mar 30, 2019·Stem Cells Translational Medicine·Hocine Rachid HocineReem Al-Daccak
Feb 23, 2019·Current Opinion in Cardiology·Priyatansh Gurha
May 24, 2019·Circulation Research·Todd R HeallenJames F Martin
Jul 7, 2018·Nature Biotechnology·Wolfram-Hubertus Zimmermann
Jun 6, 2019·Annual Review of Biomedical Engineering·Marc A SimonHarvey S Borovetz
Aug 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Zhaoning WangEric N Olson
Mar 10, 2020·Experimental Biology and Medicine·Ying XiaoY James Kang
Feb 13, 2020·Chinese Medical Journal·Chong DuLian-Sheng Wang
Sep 15, 2020·Histochemistry and Cell Biology·Rebecca RyanRebecca J Richardson
May 8, 2018·Stem Cells International·James L Engel, Reza Ardehali
Jun 16, 2018·Current Cardiology Reports·John P Leach, James F Martin
Nov 13, 2018·Npj Regenerative Medicine·Rebecca J Richardson
Dec 6, 2019·International Journal of Molecular Sciences·Karin JennbackenLovisa Holmberg Schiavone
Nov 29, 2019·Advanced Healthcare Materials·Jeffrey J D HenrySong Li
Aug 11, 2020·Stem Cell Research & Therapy·Xiaomo WuXiaolong Liu
Jun 29, 2018·Nature Reviews. Cardiology·Jingli Cao, Kenneth D Poss
Oct 19, 2018·Korean Circulation Journal·Misun Park, Young Sup Yoon
Sep 30, 2018·Scientific Reports·Vasily A PopkovDmitry B Zorov
May 23, 2019·Cell Proliferation·Yi-Zhou TanBei Li
Jun 2, 2020·Frontiers in Bioengineering and Biotechnology·Edoardo MaghinSveva Bollini
Jan 18, 2018·Journal of Cellular and Molecular Medicine·Deliang ShenThomas G Caranasos


Nov 21, 1992·Journal of Theoretical Biology·R J Goss
Jul 11, 1992·Lancet·M Packer
Aug 6, 1999·Gene Therapy·J Fujimoto, Y Kaneda
Feb 24, 2001·Lancet·Philippe MenaschéJean-Pierre Marolleau
Apr 5, 2001·Nature·D OrlicP Anversa
Aug 16, 2001·The Anatomical Record·N HuE B Clark
Dec 14, 2002·Science·Kenneth D PossMark T Keating
May 26, 2004·The Journal of Biological Chemistry·Hina W ChaudhryDebra J Wolgemuth
Jul 16, 2004·The Biochemical Journal·Katrina A BicknellGavin Brooks
Feb 15, 2005·Developmental Biology·Vladimir VinarskyShannon J Odelberg
May 5, 2005·Genes & Development·Felix B EngelMark T Keating
Nov 26, 2005·The Anatomical Record. Part B, the New Anatomist·Bruce M Carlson
Mar 28, 2006·Nature Chemical Biology·Peter E BaylissJoanne Chan
May 24, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hideo KanemitsuMasashi Komeda
Sep 23, 2006·The New England Journal of Medicine·Ketil LundeKolbjørn Forfang
Sep 23, 2006·The New England Journal of Medicine·Volker SchächingerREPAIR-AMI Investigators
Sep 29, 2006·Journal of Anatomy·James W Godwin, Jeremy P Brockes
Oct 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Felix B EngelMark T Keating
Oct 19, 2006·Nature Reviews. Genetics·Alejandro Sánchez Alvarado, Panagiotis A Tsonis
Nov 24, 2006·Nature Clinical Practice. Cardiovascular Medicine·Jagat NarulaY Chandrashekhar
Apr 13, 2007·Physiological Reviews·Preeti AhujaW Robb MacLellan
May 3, 2007·JAMA : the Journal of the American Medical Association·Paul W Armstrong, Christopher B Granger
Aug 31, 2007·Histopathology·Y IshikawaT Ishii
Nov 21, 2007·The Journal of Experimental Medicine·Matthias NahrendorfMikael J Pittet
Jan 23, 2008·The Journal of Experimental Medicine·Masashi ShimazakiAkira Kudo
Apr 5, 2008·Journal of the American College of Cardiology·Marcin BujakNikolaos G Frangogiannis
Jul 17, 2008·Cardiovascular Research·Henning EbeltThomas Braun
Oct 29, 2008·Circulation·Raghava S VelagaletiRamachandran S Vasan
Jan 3, 2009·Journal of the American College of Cardiology·Justin A EzekowitzFinlay A McAlister

Related Concepts

Biochemical Pathway
Immune System
Extracellular Matrix
Stem Cell Transplant
Cardiomyocyte Proliferation
Myocardial Infarction
Cellular Reprogramming
Stimulation Procedure

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